Norisoboldine hydrochloride (Synonyms: (+)-Laurelliptine hydrochloride)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Norisoboldine hydrochloride  (Synonyms: (+)-Laurelliptine hydrochloride)

Norisoboldine hydrochloride 是一种具有口服活性的天然芳基烃受体 (AhR) 激动剂。Norisoboldine 作为林参中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。

Norisoboldine hydrochloride (Synonyms: (+)-Laurelliptine hydrochloride)

Norisoboldine hydrochloride Chemical Structure

CAS No. : 5083-84-1

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生物活性

Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor (AhR) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of Rheumatoid arthritis and Ulcerative colitis[1][2].

IC50 & Target

AhR[2]
体外研究
(In Vitro)

Norisoboldine hydrochloride (1~30 μM; 0~24 hours; CD4+T cells) activates AhR under hypoxic microenvironment and significantly downregulates mRNA expression of miR-31[2].
Norisoboldine hydrochloride (30 μM; 0~24 hours; CD4+T cells) inhibits glycolysis in hypoxia[2].
Norisoboldine hydrochloride (1~30 μM; 0~72 hours; Treg cells) promotes Treg differentiation in hypoxia[2].
Norisoboldine hydrochloride (10, 30 μM) facilitates the disassociation of HSP90/AhR complexes, the nuclear translocation of AhR, and the formation of AhR/ARNT complexes. Norisoboldine hydrochloride induces generation of Treg cells in hypoxia[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Norisoboldine hydrochloride 相关抗体:

Western Blot Analysis[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Activated AhR in cells under hypoxic microenvironment.

RT-PCR[2]

Cell Line: CD4+T cells
Concentration: 1~30 μM
Incubation Time: 24 hours
Result: Significantly downregulated mRNA expression of miR-31.

Immunofluorescence[2]

Cell Line: CD4+T cells
Concentration: 30 μM
Incubation Time: 24 hours
Result: Inhibited glycolysis in hypoxia.

Immunofluorescence[2]

Cell Line: Treg cells
Concentration: 1~30 μM
Incubation Time: 72 hours
Result: Promoted Treg differentiation in hypoxia.

体内研究
(In Vivo)

Norisoboldine hydrochloride (10~40 mg/kg; p.o.; 20 days) significantly reduces the severity of joint swelling and erythema during the course of the experiment[1].
Norisoboldine hydrochloride (40 mg/kg; i.g.; 10 days) induces enhancement of CYP1A1 expression and suppresses expressions of Glut1 and HK2 in colons[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (18–22 g)
Dosage: 10~40 mg/kg
Administration: P.o.
Result: Significantly reduced the severity of joint swelling and erythema during the course of the experiment.
Animal Model: Female C57BL/6 mice (18–22 g)
Dosage: 40 mg/kg
Administration: I.g.
Result: Induced enhancement of CYP1A1 expression and suppressed expressions of Glut1 and HK2 in colons.

分子量

349.81

Formula

C18H20ClNO4
CAS 号

5083-84-1
中文名称

去甲异波尔定（盐酸盐）； 去甲基异波尔定（盐酸盐）； 新木姜子碱（盐酸盐）； 去甲依波而定（盐酸盐）
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 樟科
  • 乌药
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (541 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Luo Y, et al. Therapeutic effect of norisoboldine, an alkaloid isolated from Radix Linderae, on collagen-induced arthritis in mice. Phytomedicine. 2010;17(10):726-731.  [Content Brief]

    [2]. Lv Q, et al. Norisoboldine, a natural AhR agonist, promotes Treg differentiation and attenuates colitis via targeting glycolysis and subsequent NAD+/SIRT1/SUV39H1/H3K9me3 signaling pathway. Cell Death Dis. 2018;9(3):258. Published 2018 Feb 15.  [Content Brief]

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