Geissoschizoline (Synonyms: (+)-Geissoschizoline)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Geissoschizoline  (Synonyms: (+)-Geissoschizoline)

Geissoschizoline ((+)-Geissoschizoline) 是一种有效的人 AChE/BChE 抑制剂，其IC50s 分别为 20.40 µM 和 10.21 µM。Geissoschizoline 可用于预防神经变性和恢复神经传递方面的研究。Geissoschizoline 还具有抗炎作用。

Geissoschizoline (Synonyms: (+)-Geissoschizoline)

Geissoschizoline Chemical Structure

CAS No. : 18397-07-4

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Geissoschizoline 相关产品

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生物活性

Geissoschizoline ((+)-Geissoschizoline) is a potent inhibitor of human AChE/BChE, with IC50s of 20.40 µM and 10.21 µM, respectively. Geissoschizoline emerges as a possible multi-target prototype that can be very useful in studies of preventing neurodegeneration and restoring neurotransmission. Geissoschizoline aiso is a potent anti-inflammatory agent[1].

IC50 & Target

IC50: 20.40 µM (AChE), 10.21 µM (BChE)[1]
体外研究
(In Vitro)

Geissoschizoline(1 μM; 48 hours) significantly reduces production of TNF-α and NO in LPS-stimulated microglial cells [1].
Geissoschizoline(1, 10 and 30 μM; 24 hours) shows no cytotoxicity to LPS-stimulated microglial cells[1]

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Geissoschizoline 相关抗体:

Cell Viability Assay[1]

Cell Line: LPS-stimulated microglial cells (pre-incubated with various concentrations (0.1- 10 μM) of geissoschizoline for 1 hour)
Concentration: 1 μM
Incubation Time: 48 hours
Result: Reduced neuroinflammation and increased neuroprotection, also restored synaptic transmission.

Cell Cytotoxicity Assay[1]

Cell Line: LPS-stimulated microglial cells
Concentration: 1, 10 and 30 μM
Incubation Time: 24 hours
Result: Did not affect cell viability.

分子量

298.42

Formula

C19H26N2O
CAS 号

18397-07-4
结构分类
  • Alkaloids
  • Pyrrole Alkaloids
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 植物
  • 凤尾蕨科
  • 西南凤尾蕨
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (536 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Josélia A Lima, et al. Geissoschizoline, a promising alkaloid for Alzheimer’s disease: Inhibition of human cholinesterases, anti-inflammatory effects and molecular docking. Bioorg Chem. 2020 Nov;104:104215.  [Content Brief]

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