Liriodenine (Synonyms: Spermatheridine; VLT045)

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Liriodenine  (Synonyms: Spermatheridine; VLT045)

Liriodenine (Spermatheridine;VLT045) 是从植物 Mitrephora sirikitiae 中分离出来的，具有抗癌活性。Liriodenine 诱导细胞凋亡 (apoptosis)，通过诱导 caspase-3 和 caspase-9 激活其内在通路。

Liriodenine (Synonyms: Spermatheridine; VLT045)

Liriodenine Chemical Structure

CAS No. : 475-75-2

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Liriodenine 相关产品

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生物活性

Liriodenine (Spermatheridine; VLT045) is an aporphine alkaloid isolated from the plant Mitrephora sirikitiae and has anti-cancer activities[1]. Liriodenine induces cell apoptosis, activates the intrinsic pathway by induction of caspase-3 and caspase-9[2].

体外研究
(In Vitro)

Liriodenine is against P-388, KB, HT-29, MCF-7, A549, ASK and Hek-293 cells with IC50 values of 9.60 μM, 11.02 μM, 10.62 μM, 9.20 μM and 8.07μM, respectively.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Liriodenine 相关抗体:
分子量

275.26

Formula

C17H9NO3
CAS 号

475-75-2
结构分类
  • Alkaloids
  • Pyridine Alkaloids
初始来源
  • 植物
  • 木兰科
  • 鹅掌楸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Natthinee Anantachoke, et al. Cytotoxic Compounds From the Leaves and Stems of the Endemic Thai Plant Mitrephora sirikitiae. Pharm Biol  [Content Brief]

    [2]. Noraziah Nordin, et al. Liriodenine, an Aporphine Alkaloid From Enicosanthellum Pulchrum, Inhibits Proliferation of Human Ovarian Cancer Cells Through Induction of Apoptosis via the Mitochondrial Signaling Pathway and Blocking Cell Cycle Progression. Drug  [Content Brief]

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