Saikogenin D (Synonyms: 皂苷元 D)

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Saikogenin D  (Synonyms: 皂苷元 D) 纯度: 98.95%

Saikogenin D 分离自 Bupleurum chinense ，具有抗炎作用。Saikogenin D 激活环氧合酶，将花生四烯酸转化为环氧二十烷酸和二羟基二十碳三烯酸，其代谢产物继而抑制前列腺素E2 (PGE2) 的产生。 由于细胞内 Ca2+ 的释放，Saikogenin D 导致 [Ca2+]i 升高。

Saikogenin D (Synonyms: 皂苷元 D)

Saikogenin D Chemical Structure

CAS No. : 5573-16-0

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Saikogenin D 相关产品

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生物活性

Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca2+]i due to Ca2+ release from intracellular stores[1][2].

体外研究
(In Vitro)

Saikogenin D (1-20 μM) inhibits PGE2 production induced by the Ca2+ ionophore A23187 in a concentration-dependent manner with an IC50 value of 3 μM in C6 rat glioma cells[1].
Saikogenin D (10-100 μM) elevates [Ca2+]i in a concentration-dependent manner with a EC50 value of 35 μM in the presence or absence of extracellular Ca2+ in C6 rat glioma cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Saikogenin D 相关抗体:
分子量

472.70

Formula

C30H48O4
CAS 号

5573-16-0
性状

固体

颜色

White to off-white

中文名称

皂苷元 D
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 菊科
  • 伞序托鞭菊
  • 植物
  • 伞形科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 98.95%

Data Sheet (533 KB) SDS (393 KB)

COA (267 KB) HNMR (349 KB) RP-HPLC (250 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Toriniwa Y, et al. Participation of epoxygenase activation in saikogenin D-induced inhibition of prostaglandin E(2) synthesis.J Pharm Pharmacol. 2006 Jun;58(6):859-66.  [Content Brief]

    [2]. Kodama Y, et al. Dual effect of saikogenin D: in vitro inhibition of prostaglandin E2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells.Planta Med. 2003 Aug;69(8):765-7.  [Content Brief]

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