Guanfu base G

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Guanfu base G 

Guanfu base G 是一种从 Aconitum coreanum 中分离的抗心律失常生物碱。Guanfu base G 以 IC50 值为 17.9 μM 来抑制 HERG 通道电流。

Guanfu base G

Guanfu base G Chemical Structure

CAS No. : 78969-72-9

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生物活性

Guanfu base G is an antiarrhythmic alkaloid isolated from Aconitum coreanum. Guanfu base G inhibits HERG channel current with an IC50 of 17.9 μM[1][2].

IC50 & Target

IC50: 17.9 μM (HERG channel)[2]
体外研究
(In Vitro)

The effects of Guanfu base G is investigated in human embryonic kidney 293 (HEK293) cells transiently transfected with HERG complementary DNA using a whole-cell patch clamp technique. Guanfu base G inhibits HERG channel current in concentration-, voltage-, and time-dependent manners. Guanfu base G shifts the activation curve in a negative direction and accelerated channel inactivation but shows no effect on the inactivation curve. Moreover, Guanfu base G also accelerates channel recovery from inactivation[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Guanfu base G 相关抗体:
体内研究
(In Vivo)

Guanfu base G (5 mg/kg; intravenous injection; for 5-1200 minutes; rats) treatment in rats after 15 min could be detected the presence of Guanfu base A, about 10% of Guanfu base G in vivo could metabolize to Guanfu base A, which may be related to the metabolic enzymes in the body and its nature-related compounds, however, the substance in the body to eliminate more quickly, could be detected only around 240 min. The pharmacokinetic behavior of Guanfu base G is better in rats, the T1/2 is 4.16 hours. These results indicate that Guanfu base G has a relatively suitable elimination half-life[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[1]
Dosage: 5 mg/kg
Administration: Intravenous injection; for 5, 15, 30, 45, 60, 120, 240, 360, 480, 600, 720, 960 and 1200 minutes (Pharmacokinetic study)
Result: The pharmacokinetic behavior was better in rats, the T1/2 was 4.16 hours.

分子量

471.54

Formula

C26H33NO7
CAS 号

78969-72-9
结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 植物
  • 毛茛科
  • 乌头
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zhang L, et al. Simultaneous determination of Guanfu base G and its active metabolites by UPLC-MS/MS in rat plasma and its application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Apr 15;957:1-6.  [Content Brief]

    [2]. Huang X, et al. Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83.  [Content Brief]

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