Enmein

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Enmein 

Enmein 从 I. serra 中分离，具有免疫抑制作用。

Enmein

Enmein Chemical Structure

CAS No. : 3776-39-4

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生物活性

Enmein is isolated from I. serra with immunosuppressive effect[1].

体外研究
(In Vitro)

Enmein shows significant inhibitory effect toward K562 with an IC50 value ranging from 3.2 μg/ml to 8.2 μg/ml[2].
Enmein (3.13-25 μg/ml; 48 hours) has inhibitory effect on lymphocytes with significant difference within concentration from 6.25 μg/ml to 25 μg/ml[1].
Enmein (5.5-22 μg/ml; 48 hours) causes the percentage of S stage cells decreased from 19% to 6%, causes the percentage of G2/M stage cells to decrease from 2% to 0.4%[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Enmein 相关抗体:

Cell Viability Assay[1]

Cell Line: Splenic lymphocyte cells
Concentration: 3.13, 6.25, 12.5, 25 μg/ml
Incubation Time: 48 hours
Result: Exhibited an IC50 value of 17 μg/ml in splenic lymphocytes.

Cell Cycle Analysis[1]

Cell Line: Splenic lymphocyte cells
Concentration: 5.5 μg/ml, 11 μg/ml, 22 μg/ml
Incubation Time: 48 hours
Result: Caused S stage cells and G2/M stage cells decreased.

体内研究
(In Vivo)

Enmein (inject to ear; 6.52-13.04 mg/kg; 5 days) inhibits the xylene-induced ear swelling and inhibits IL-2 expression[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c mice[1]
Dosage: 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg
Administration: Injected to ear; 6.52 mg/kg, 9.78 mg/kg or 13.04 mg/kg; 5 days
Result: Had inhibitory effect on IL-2 release in blood.

分子量

362.42

Formula

C20H26O6
CAS 号

3776-39-4
结构分类
  • Others
初始来源
  • 植物
  • 菊科
  • Baccharis darwinii Hook. & Arn.
  • 植物
  • 唇形科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zhang Y, et al. Distinct immunosuppressive effect by Isodon serra extracts. Int Immunopharmacol. 2005 Dec;5(13-14):1957-65. Epub 2005 Jul 13.  [Content Brief]

    [2]. Jiang B, et al. Cytotoxic ent-kaurane diterpenoids from Isodon sculponeata. Planta Med. 2002 Oct;68(10):921-5.  [Content Brief]

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