Gitogenin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Gitogenin  纯度: 99.82%

Gitogenin 是从 Tribulus longipetalus 整株中分离出来的一种天然类固醇，是 UDP-葡萄糖醛酸转移酶 1A4 (UGT1A4) 和 α-葡萄糖苷酶的选择性抑制剂，其 IC50 值分别为 0.69 µM (使用三氟拉嗪为底物) 和 37.2 μM，并且不抑制人类主要细胞色素 P450 亚型的活性。

Gitogenin

Gitogenin Chemical Structure

CAS No. : 511-96-6

规格 价格 是否有货 数量
1 mg ￥902 In-stock
5 mg ￥2370 In-stock
10 mg ￥4030 In-stock
20 mg ￥6860 In-stock
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Gitogenin 相关产品

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生物活性

Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms[1][2].

IC50 & Target

IC50: 0.69 µM (UDP-glucuronosyltransferase 1A4)[1]; IC50: 37.2 μM (α-glucosidase)[2]
体外研究
(In Vitro)

When tamoxifen is used as the substrate metabolized by UGT1A4 in HLMs, Gitogenin exhibits potent inhibition of tamoxifen, with an IC50 value of 6.13 µM. Similarly, for midazolam as the substrate of UGT1A4, the IC50 value is 5.7 µM. In addition, when olanzapine is used as a substrate of UGT1A4, the IC50 value is determined as 6.0 µM. Finally, we also evaluats Gitogenin for asenapine glucuronidation mediated by UGT1A4, and similar inhibition effect is observed, with an IC50 value of 22.0 µM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Gitogenin 相关抗体:
体内研究
(In Vivo)

Stimulation of growth hormone release is investigated on rat pituitary cells in vitro. Gitogenin (20 μg/mL) shows rat growth-hormone (rGH) release stimulating activities (26.1 ng/mL)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

432.64

Formula

C27H44O4
CAS 号

511-96-6
性状

固体

颜色

White to off-white

结构分类
  • Steroids
初始来源
  • 植物
  • 蒺藜科
  • 蒺藜
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 1.85 mg/mL (4.28 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3114 mL 11.5570 mL 23.1139 mL
5 mM — — —
10 mM — — —

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

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浓度 (final)

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体积 (final)

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给药剂量

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.82%

Data Sheet (610 KB) SDS (393 KB)

COA (265 KB) HNMR (88 KB) CNMR (93 KB) RP-HPLC (126 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Xu M, et al. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol Res. 2016 Aug;110:139-150.  [Content Brief]

    [2]. Xu M, et al. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction. Pharmacol Res. 2016 Aug;110:139-150.

    [3]. Naveed MA, et al. Longipetalosides A-C, new steroidal saponins from Tribulus longipetalus. Steroids. 2014 May;83:45-51.  [Content Brief]

    [4]. Shim SH, et al. Rat growth-hormone release stimulators from fenugreek seeds. Chem Biodivers. 2008 Sep;5(9):1753-61.  [Content Brief]

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