5,7,3′,4′-Tetramethoxyflavone (Synonyms: 木犀草素四甲醚)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
5,7,3′,4′-Tetramethoxyflavone  (Synonyms: 木犀草素四甲醚) 纯度: 98.66%

5,7,3′,4′-Tetramethoxyflavone 是可以从 M. exotica 中分离得到的一种具有口服活性的多甲氧基黄酮，具有多种生物活性，包括抗真菌、抗疟疾、抗分支杆菌和抗炎活性。5,7,3′,4′-Tetramethoxyflavone 可通过靶向 β-catenin 发挥软骨保护作用。

5,7,3

5,7,3′,4′-Tetramethoxyflavone Chemical Structure

CAS No. : 855-97-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥539 In-stock
5 mg ￥490 In-stock
10 mg ￥770 In-stock
50 mg ￥1900 In-stock
100 mg   询价  
200 mg   询价  

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5,7,3′,4′-Tetramethoxyflavone 相关产品

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生物活性

5,7,3′,4′-Tetramethoxyflavone, an orally active polymethoxyflavones (PMFs) that can be isolated from M. exotica, possesses various bioactivities, including anti-fungal, anti-malarial, anti-mycobacterial, and anti-inflammatory activities. 5,7,3′,4′-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling[1].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

5,7,3′,4′-Tetramethoxyflavone (5-20 μg/mL, 24 h) 抑制软骨细胞中 EP2、EP4、bcatenin 和 COX-2 基因的表达[1]。
5,7,3′,4′-Tetramethoxyflavone (5-20 μg/mL, 48 h) 抑制软骨细胞中 EP/cAMP/PKA 信号通路和 β-catenin 信号通路蛋白的表达[1]。
5,7,3′,4′-Tetramethoxyflavone (5-20 μg/mL, 4 h) 通过调节IRE1α保护软骨细胞免于凋亡[2]。
5,7,3′,4′-Tetramethoxyflavone (5-20 μg/mL, 4 h) 可逆转 IRE1α 缺乏导致的内质网 (ER) 应激基因的表达模式[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

5,7,3′,4′-Tetramethoxyflavone 相关抗体:

Cell Line:
Concentration:
Incubation Time:
Result:

Western Blot Analysis[2]

Cell Line: Chondrocytes
Concentration: 5-20 μg/mL
Incubation Time: 4 h
Result: Increased the protein level of Bcl-2 and XBP1s.
Decreased the expression of pro-apoptotic factors CHOP/caspase-3 and stress kinase JNK.

体内研究
(In Vivo)

5,7,3′,4′-Tetramethoxyflavone (25-100 mg/kg, 灌胃) 在大鼠体内表现出软骨保护活性[1]。
5,7,3′,4′-Tetramethoxyflavone (5-20 mg/kg; 静脉注射, 口服) 在大鼠中绝对生物利用度为 14.3 %[3]。
1.19
药代动力学分析[3]

Route Dose (mg/kg) AUC (min μg/mL) AUC/Dose (min/mL) t1/2 (h) Tmax (h) Cmax (ng/mL) Bioavailability (%)
i.v. 5 161.49 ± 58.78 0.1154 ± 0.0420 62.85 ± 27.92 / / 14.3
p.o. 50 231.43 ± 71.87 0.0165 ± 0.0051 273.76 ± 90.23 190.34 ± 24.50 0.79 ± 0.30 /

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat knee OA model[1]
Dosage: 25-100 mg/kg
Administration: i.g.
Result: Decreased the contents of IL-1b, TNF-a, and PGE2 in a dose-dependent manner.
Decreases the expression of the inflammatory cytokines in rat knee osteoarthritis (OA) synovial fluid (SF) lavages.
Inhibited chondrocytes hypertrophy and decreased the cartilage thickness.
Exhibited down regulation of b-catenin in a dose-dependent manner.

分子量

342.35

Formula

C19H18O6
CAS 号

855-97-0
性状

固体

颜色

White to off-white

中文名称

木犀草素四甲醚
结构分类
  • Flavonoids
  • Flavones
初始来源
  • 植物
  • 芸香科
  • 九里香
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 8.33 mg/mL (24.33 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9210 mL 14.6049 mL 29.2099 mL
5 mM 0.5842 mL 2.9210 mL 5.8420 mL
10 mM 0.2921 mL 1.4605 mL 2.9210 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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体积

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

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浓度 (final)

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体积 (final)

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.15%

Data Sheet (608 KB) SDS (393 KB)

COA (264 KB) RP-HPLC (277 KB) LCMS (266 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Wu L, et al. 5,7,3′,4′-Tetramethoxyflavone exhibits chondroprotective activity by targeting β-catenin signaling in vivo and in vitro. Biochem Biophys Res Commun. 2014 Sep 26;452(3):682-8.  [Content Brief]

    [2]. Wu L, et al. 5,7,3′,4′-Tetramethoxyflavone protects chondrocytes from ER stress-induced apoptosis through regulation of the IRE1α pathway. Connect Tissue Res. 2018 Mar;59(2):157-166.  [Content Brief]

    [3]. Wei G, et al. Absolute bioavailability, pharmacokinetics and excretion of 5,7,30 ,40 -tetramethoxyflavone

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