上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Nosiheptide (Synonyms: 那西肽; Multhiomycin; RP 9671) 纯度: 97.05%
Nosiheptide (Multhiomycin) 是一种由 Streptomyces actuosus 产生的硫肽抗生素，可抑制细菌蛋白质的合成，并在独特的大环核上具有独特的吲哚侧环系统和区域特异性羟基，已被广泛用作动物生长的饲料添加剂。
Nosiheptide Chemical Structure
CAS No. : 56377-79-8
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 10 mM * 1 mL in DMSO | ￥5916 | In-stock | |
| 1 mg | ￥666 | In-stock | |
| 2 mg | ￥1219 | In-stock | |
| 5 mg | ￥2438 | In-stock | |
| 10 mg | ￥4213 | In-stock | |
| 25 mg | ￥6447 | In-stock | |
| 100 mg | 询价 |
* Please select Quantity before adding items.
Nosiheptide 相关产品
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| 生物活性 |
Nosiheptide (Multhiomycin), a thiopeptide antibiotic produced by Streptomyces actuosus, inhibits bacterial protein synthesis and bears a unique indole side ring system and regiospecific hydroxyl groups on the characteristic macrocyclic core. Nosiheptide has been widely used as a feed additive for animal growth[1][2]. |
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| 体外研究 (In Vitro) |
Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti-Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
Nosiheptide (20 mg/kg; intraperitoneal injection; injected at 1 and 8 h post-infection; female CD1 mice) provids significant protection against mortality. Ten out of 10 of the Nosiheptide-treated mice remains alive on day 3, while 6/10 of the controls died on day 1[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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| 分子量 |
1222.36 |
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| Formula |
C51H43N13O12S6 |
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| CAS 号 |
56377-79-8 |
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| 性状 |
固体 |
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| 颜色 |
Light yellow to yellow |
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| 中文名称 |
那西肽 |
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| 结构分类 |
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| 初始来源 |
Streptomyces actuosus |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 100 mg/mL (81.81 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
请输入动物实验的基本信息：
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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| 纯度 & 产品资料 |
纯度: 97.05%
Data Sheet (608 KB) SDS (393 KB)
COA (204 KB) LCMS (270 KB) 产品使用指南 (1538 KB) |
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| 参考文献 |
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