Cetirizine (Synonyms: 西替利嗪) | Axygen爱思进官网

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Cetirizine (Synonyms: 西替利嗪) 纯度: 99.51%

Cetirizine 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。

Cetirizine Chemical Structure

CAS No. : 83881-51-0

规格	价格	是否有货
50 mg	￥250	In-stock
100 mg	￥400	In-stock
200 mg		询价
500 mg		询价

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生物活性

Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response^[1]^[2]^[3].

体外研究
(In Vitro)

Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist^{[2]^.}

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cetirizine 相关抗体:

Cell Viability Assay^[2]

Cell Line:	Human airway epithelial cell line A549.
Concentration:	0-10 μM.
Incubation Time:	24 h.
Result:	The survival of A549 cells incubated with various concentrations of cetirizine (0.1, 1, 2.5, 5, and 10 μM) for 24 hours were all higher than 90% when comparing with the control group by MTT test. Cetirizine, 5 and 10 μM, suppressed GM-CSF release by 70.71 and 61.55%, respectively. Preincubation with cetirizine, 10 μM, suppressed the IL-8 secretion by 75.04%.

体内研究
(In Vivo)

Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen^{[3]^.}

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male 8-week-old BALB/c mice (25-30 g) immunized and challenged with ragweed pollen^{[3]^.}
Dosage:	2 or 20 mg/kg.
Administration:	Orally, diluted in sterile water on days 18, 19, and 20.
Result:	The neutrophilia at 8 h and eosinophilia at 24 h induced by ragweed pollen extract per os were significantly reduced in the mice treated with 20 mg/kg. The dosage with 2 mg/kg had no effect.

Clinical Trial

分子量

388.89

Formula

C₂₁H₂₅ClN₂O₃

CAS 号

83881-51-0

性状

固体

颜色

Off-white to light yellow

中文名称

西替利嗪；西替利嗪

结构分类

Ketones, Aldehydes, Acids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO 中的溶解度 : 250 mg/mL (642.86 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5714 mL	12.8571 mL	25.7142 mL
5 mM	0.5143 mL	2.5714 mL	5.1428 mL
10 mM	0.2571 mL	1.2857 mL	2.5714 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

方案一

Cetirizine is dissolved in PBS^[6].

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.51%

选择批次：

Data Sheet (605 KB) SDS (393 KB)

COA (167 KB) HNMR (268 KB) LCMS (87 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055•1080, 1993.

[2]. Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5. [Content Brief]

[3]. Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9. [Content Brief]

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Cetirizine 相关抗体:

摩尔计算器

稀释计算器