Randialic acid B

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Randialic acid B  纯度: 99.94%

Randialic acid B 是一种三萜化合物，是一种甲酰肽受体 1 (FPR1) 拮抗剂。Randialic acid B 阻断人中性粒细胞中的 FPR1 并在体内减轻银屑病样炎症。

Randialic acid B

Randialic acid B Chemical Structure

CAS No. : 14021-14-8

规格 价格 是否有货 数量
1 mg ￥2240 In-stock
5 mg ￥5760 In-stock
10 mg ￥8928 In-stock
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Randialic acid B 相关产品

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生物活性

Randialic acid B, a triterpenoid compound, is a formyl peptide receptor 1 (FPR1) antagonist. Randialic acid B blocks FPR1 in human neutrophils and attenuates psoriasis-like inflammation in vivo[1].

体外研究
(In Vitro)

Randialic acid B (0.1-3 μM; for 5 min) selectively inhibits reactive oxygen species production, elastase release, and CD11b expression in human neutrophils activated by FPR1. Randialic acid B inhibits the binding of N-formyl peptide to FPR1 in human neutrophils, neutrophil-like THP-1 cells, and hFPR1-transfected HEK293 cells, indicating FPR1 antagonism[1].
Randialic acid B acts competitively for its binding to the FPR1 receptor. The FPR1-downstream signaling such as Ca2+ mobilisation and activation of Akt and MAPKs is also competitively inhibited[1].
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Randialic acid B 相关抗体:
体内研究
(In Vivo)

Randialic acid B (10 mg/kg; i.v.; every other day; for 5 days) significantly reduces Imiquimod-induced psoriasis-like symptom, including epidermal hyperplasia, desquamation with scaling, neutrophil skin infiltration, and transepidermal water loss[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c white female mice (20 g weight; 7-week-old) treated with Imiquimod[1]
Dosage: 10 mg/kg
Administration: i.v.; every other day; for 5 days
Result: Significantly reduced Imiquimod-induced psoriasis-like symptoms.

分子量

454.68

Formula

C30H46O3
CAS 号

14021-14-8
性状

固体

颜色

White to off-white

结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 冬青科
  • 毛冬青
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (219.93 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1993 mL 10.9967 mL 21.9935 mL
5 mM 0.4399 mL 2.1993 mL 4.3987 mL
10 mM 0.2199 mL 1.0997 mL 2.1993 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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纯度 & 产品资料

纯度: 99.94%

Data Sheet (602 KB) SDS (251 KB)

COA (267 KB) HNMR (297 KB) CNMR (135 KB) RP-HPLC (137 KB) MS (79 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Michal Korinek, et al. Randialic acid B and tomentosolic acid block formyl peptide receptor 1 in human neutrophils and attenuate psoriasis-like inflammation in vivo. Biochem Pharmacol. 2021 Aug;190:114596.  [Content Brief]

    [2]. Shan-Shan Li, et al. Three new triterpenoids isolated from the aerial parts of Ilex cornuta and protective effects against H 2 O 2-induced myocardial cell injury. Chin J Nat Med. 2017 Feb;15(2):115-120.  [Content Brief]

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