Stearoyl-L-carnitine chloride

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Stearoyl-L-carnitine chloride  纯度: ≥98.0%

Stearoyl-L-carnitine chloride 是一种内源性的长链酰基肉碱。Stearoyl-L-carnitine chloride 是一种效力较弱的 GlyT2 抑制剂。Stearoyl-L-carnitine chloride 在浓度高达 3 μM 时可抑制 16.8％ 的甘氨酸响应。

Stearoyl-L-carnitine chloride

Stearoyl-L-carnitine chloride Chemical Structure

CAS No. : 32350-57-5

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Stearoyl-L-carnitine chloride 相关产品

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生物活性

Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].

IC50 & Target[2]

GlyT2

 

体外研究
(In Vitro)

Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in Xenopus laevis oocytes[2].
Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na+-dependent [3H]carnitine (20 nM) uptake by ~50% in HPCT cells[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Stearoyl-L-carnitine chloride 相关抗体:
体内研究
(In Vivo)

Stearoyl-L-carnitine is significantly decreased in Alzheimer’s disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

464.12

Formula

C25H50ClNO4
CAS 号

32350-57-5
性状

固体

颜色

White to off-white

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (10.77 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1546 mL 10.7731 mL 21.5462 mL
5 mM 0.4309 mL 2.1546 mL 4.3092 mL
10 mM 0.2155 mL 1.0773 mL 2.1546 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

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给药剂量

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (597 KB) SDS (251 KB)

COA (256 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer’s Dementia. PLoS One. 2016 May 19;11(5):e0155694.  [Content Brief]

    [2]. Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902.  [Content Brief]

    [3]. Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58(8):1361-70.  [Content Brief]

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