L-Sepiapterin (Synonyms: Sepiapterin)

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L-Sepiapterin  (Synonyms: Sepiapterin)

L-Sepiapterin (Sepiapterin) 是内皮型一氧化氮合酶 (eNOS) 辅因子四氢生物喋呤 (BH4) 的前体。L-Sepiapterin 改善 db/db 小鼠肠系膜小动脉内皮功能障碍，诱导血管生成。L-Sepiapterin 通过下调 p70S6K 依赖性 VEGFR-2 表达抑制卵巢癌细胞增殖和迁移。

L-Sepiapterin (Synonyms: Sepiapterin)

L-Sepiapterin Chemical Structure

CAS No. : 17094-01-8

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生物活性

L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner[1].
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70S6K[1].
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

L-Sepiapterin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: SKOV-3 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 24 hours
Result: Induced cell proliferation in a dose-dependent manner.

体内研究
(In Vivo)

Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/KsJ diabetic mice (db/db)[2]
Dosage: 10 mg/kg
Administration: P.o. (powder chow); daily for or 8 weeks
Result: Significantly improved the relaxation to Ach in SMA from db/db mice.

分子量

237.22

Formula

C9H11N5O3
CAS 号

17094-01-8
性状

固体

颜色

White to yellow

结构分类
  • Alkaloids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

Data Sheet (534 KB) SDS (251 KB)

COA (192 KB) 元素分析报告 (209 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Pannirselvam M, et al. Chronic oral supplementation with sepiapterin prevents endothelial dysfunction and oxidative stress in small mesenteric arteries from diabetic (db/db) mice. Br J Pharmacol. 2003;140(4):701‐706.  [Content Brief]

    [2]. Cho YR, et al. Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression. Oncol Rep. 2011;26(4):861‐867.  [Content Brief]

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