2′-Fucosyllactose (Synonyms: 2′-FL)

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2′-Fucosyllactose  (Synonyms: 2′-FL) 纯度: ≥99.0%

2′-Fucosyllactose (2′-FL) 是一种可从母乳中提取的低聚糖。2′-Fucosyllactose 调节 CD14 的表达，缓解结肠炎，调节肠道菌群。2′-Fucosyllactose 刺激 T 细胞增加 IFN-γ 的产生和减少 IL-6, IL-17 和 TNF-α 细胞因子的产生。

2

2′-Fucosyllactose Chemical Structure

CAS No. : 41263-94-9

规格 价格 是否有货 数量
1 mg ￥400 In-stock
5 mg ￥1200 In-stock
10 mg ￥2000 In-stock
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100 mg   询价  

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生物活性

2′-Fucosyllactose (2′-FL) is an oligosaccharide that could be derived from human milk. 2′-Fucosyllactose regulates the expression of CD14, alleviates colitis and regulates the gut microbiome. 2′-Fucosyllactose stimulates T cells to increase IFN-γ production and decreases IL-6, IL-17, and TNF-α production of cytokines[1][2].

IC50 & Target

Target: IFN-γ, IL-6, IL-17, and TNF-α[1]
体外研究
(In Vitro)

2′-Fucosyllactose (2′-FL; 0-12 mg/mL; 48 h) suppress cell-associated CD14 expression and to attenuate LPS (100 μg/mL) stimulated IL-8 secretion in T84 cells[1].
2′-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) ameliorates inflammation induced by bacterial invasion. 2′-Fucosyllactose inhibits ETEC invasion and attenuated the consequent IL-8 secretion[1].
2′-Fucosyllactose (2 mg/mL; 48 h; T84 and HCT8 cells) induces macrophage migration inhibitory factor signal pathways that suppress inflammation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

2′-Fucosyllactose 相关抗体:

Western Blot Analysis[1]

Cell Line: T84 cells
Concentration: 0, 2, and 4 mg/mL
Incubation Time: 48 hours
Result: Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.

Western Blot Analysis[1]

Cell Line: T84 and HCT8 cellsT84 and HCT8 cells
Concentration: 2 mg/mL
Incubation Time: 48 hours
Result: Suppressed CD14 mRNA and reduced cell-associated CD14 protein expression.
Inhibited CD14 and NF-κB induction.
Induced iκB and SOCS2 expression and STAT3 phosphorylation.

体内研究
(In Vivo)

2′-Fucosyllactose (2′-FL; 100 mg (200 μL); i.g.; daily, for 4 d; C57BL/6 mice with AIEC infection) inhibits AIEC infection and inflammation in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (8 weeks) with AIEC (uropathogenic E. coli, and adherent-invasive E. coli) infection[1]
Dosage: 100 mg (200 μL)
Administration: Oral gavage; daily, for 4 days
Result: Had colons lengths were closer to normal.
Inhibited the colonisation of the colonic mucosa by O83-positive bacteria.
Decreased CD14 expression, CD14 mRNA levels, IL-6, IL-17 and TNF-α levels in colonic.

Clinical Trial

分子量

488.44

Formula

C18H32O15
CAS 号

41263-94-9
性状

固体

颜色

White to off-white

结构分类
  • Saccharides
  • Polysaccharides
初始来源
  • 动物

Human milk
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 50 mg/mL (102.37 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0473 mL 10.2367 mL 20.4733 mL
5 mM 0.4095 mL 2.0473 mL 4.0947 mL
10 mM 0.2047 mL 1.0237 mL 2.0473 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

V1

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C2

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体积 (final)

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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每只动物的给药体积

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工作液所需浓度 : mg/mL

该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
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纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (613 KB) SDS (251 KB)

COA (183 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. He Y, et, al. The human milk oligosaccharide 2′-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation. Gut. 2016 Jan;65(1):33-46.  [Content Brief]

    [2]. Eiwegger T, et, al. Human milk–derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Pediatr Res. 2004 Oct;56(4):536-40.  [Content Brief]

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