Tumulosic acid (Synonyms: 土莫酸)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Tumulosic acid (Synonyms: 土莫酸) 纯度: 98.31%

Tumulosic acid 是一种三萜类物质，可抑制 KLK5 蛋白酶活性 (IC₅₀=14.84 μM)。Tumulosic acid 在体外抑制角质形成细胞中 LL-37 的蛋白水解过程 (≤10 μM)。

Tumulosic acid Chemical Structure

CAS No. : 508-24-7

规格	价格	是否有货
1 mg	￥2100	In-stock
5 mg	￥4500	In-stock
10 mg		询价
50 mg		询价

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Tumulosic acid 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus

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•同靶点蛋白产品:

生物活性

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC₅₀= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM^[1].

体外研究
(In Vitro)

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC₅₀=19.3 μM)^[1].
Tumulosic acid decreases in LL-37 production in human keratinocytes^[1].
Tumulosic acid shows IC₅₀ values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Tumulosic acid 相关抗体:

Western Blot Analysis^[1]

Cell Line:	Normal human epidermal keratinocytes (NHEKs)
Concentration:	1 μM and 10 μM
Incubation Time:	23 h in the presence of 10 μM cycloheximide
Result:	Decreased LL-37 production in epidermal keratinocytes.

分子量

486.73

Formula

C₃₁H₅₀O₄

CAS 号

508-24-7

性状

固体

颜色

White to off-white

中文名称

土莫酸

结构分类

Terpenoids
Triterpenes

初始来源

植物
多孔菌科
茯苓

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 98.31%

选择批次：

Data Sheet (528 KB) SDS (393 KB)

COA (267 KB) HNMR (165 KB) CNMR (156 KB) RP-HPLC (244 KB) MS (118 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27. [Content Brief]

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