L-Canaline

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
L-Canaline  纯度: ≥95.0%

L-Canaline 是存在于许多豆科植物中的一种非蛋白质氨基酸。L-Canaline 是 L-canavanine 及其精氨酸酶催化的毒性代谢产物。L-Canaline 是一种有效且不可逆的鸟氨酸氨基转移酶抑制剂。L-Canaline 抑制疟原虫恶性疟原虫的生长，IC50 为 297 nM。L-Canaline 具有抗癌和抗增殖作用。

L-Canaline

L-Canaline Chemical Structure

CAS No. : 496-93-5

规格 价格 是否有货 数量
1 mg ￥1780 In-stock
5 mg ￥4590 In-stock
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L-Canaline 相关产品

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生物活性

L-Canaline is a nonprotein amino acid stored in many leguminous plants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and its arginase. L-Canaline is a potent and irreversible inhibitor of ornithine aminotransferase. L-Canaline inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50 of 297 nM. L-Canaline has anticancer and antiproliferative effects[1][2][3].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

L-Canaline treatment inhibits the proliferation of PBMCs after stimulation by phorbol 12-myristate-13-acetate (PMA) or via the mixed lymphocyte reaction. The greatest effect is seen with PMA-stimulated cells, where L-canaline has an IC50 of 0.26 mM. L-Canaline is slightly less toxic to PBMCs stimulated via the mixed lymphocyte reaction (IC50 of 0.54 mM)[1]. L-canaline inhibits L-lysine flux competitively (Ki of 4.6 mM) in astrocytes and astrocytoma cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

L-Canaline 相关抗体:
体内研究
(In Vivo)

L-Canaline decreases the aspartic acid content of tissues of the medulla oblongata of male Wistar rats, but it does not affect the evoked release of this nonprotein amino acid into these tissues[2].
Intraseptal injection of 100 μg of L-canaline into male Sprague-Dawley rats causes a 90% decrease in the omithine aminotransferase activity of the septum tissues evaluated from animals killed 1 h later[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

134.13

Formula

C4H10N2O3
CAS 号

496-93-5
性状

固体

颜色

White to off-white

结构分类
  • Amino acids
初始来源
  • 植物
  • 其他科
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 1 mg/mL (7.46 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.4555 mL 37.2773 mL 74.5545 mL
5 mM 1.4911 mL 7.4555 mL 14.9109 mL
10 mM — — —

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

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体积 (start)

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纯度 & 产品资料

纯度: ≥95.0%

Data Sheet (601 KB) SDS (251 KB)

COA (165 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Bence AK, et al. The antiproliferative and immunotoxic effects of L-canavanine and L-canaline. Anticancer Drugs. 2002 Mar;13(3):313-20.  [Content Brief]

    [2]. Rosenthal GA. L-canaline: a potent antimetabolite and anti-cancer agent from leguminous plants. Life Sci. 1997;60(19):1635-41.  [Content Brief]

    [3]. Berger BJ. Antimalarial activities of aminooxy compounds. Antimicrob Agents Chemother. 2000 Sep;44(9):2540-2.  [Content Brief]

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