Ganoderic acid B (Synonyms: 灵芝酸B)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Ganoderic acid B  (Synonyms: 灵芝酸B) 纯度: 99.31%

Ganoderic acid B 是从灵芝中分离出的一种三萜化合物。Ganoderic acid B 能作为端粒酶抑制剂抑制 Epstein-Barr 病毒 (EBV) 抗原的活化。Ganoderic acid B 是一种 HIV-1 protease 的中等强度抑制剂 (IC50: 170 μM)。

Ganoderic acid B (Synonyms: 灵芝酸B)

Ganoderic acid B Chemical Structure

CAS No. : 81907-61-1

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1 mg ￥1200 In-stock
5 mg ￥2900 In-stock
10 mg ￥4200 In-stock
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Ganoderic acid B 相关产品

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生物活性

Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM)[1][2][3].

IC50 & Target

HIV-1 protease[3]
体外研究
(In Vitro)

Ganoderic acid B (0-40 μM, 1 h) 降低 LPS 诱导的 A549 细胞上清液中 TNF-α、IL-6 和 IL-1β 的水平[4]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Ganoderic acid B 相关抗体:
体内研究
(In Vivo)

Ganoderic acid B (3 或 6 mg/kg，腹腔注射) 可保护小鼠免受 LPS 诱导的肺炎[4]。
Ganoderic acid B (5 mg/kg，皮下注射) 对乙酸引起的小鼠扭体具有抗伤害作用[5]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced pneumonia mice[4]
Dosage: 3 or 6 mg/kg
Administration: i.p.
Result: Reduced Lung dry/wet weight (W/D) and myeloperoxidase activity in lung.
Increased SOD, decreased MDA, TNF-α, IL-1β and IL-6 level.

分子量

516.67

Formula

C30H44O7
CAS 号

81907-61-1
性状

固体

颜色

White to light brown

中文名称

灵芝酸B
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 多孔菌科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (96.77 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9355 mL 9.6774 mL 19.3547 mL
5 mM 0.3871 mL 1.9355 mL 3.8709 mL
10 mM 0.1935 mL 0.9677 mL 1.9355 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

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动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.31%

Data Sheet (602 KB) SDS (251 KB)

COA (195 KB) HNMR (112 KB) CNMR (121 KB) RP-HPLC (191 KB) MS (118 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Zhou S, et al. Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth. Int J Med Mushrooms. 2018;20(9):859-871.  [Content Brief]

    [2]. Zheng DS, et al. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278.  [Content Brief]

    [3]. el-Mekkawy S, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7.  [Content Brief]

    [4]. Shi J, et al. Ganoderic acid B attenuates LPS-induced lung injury. Int Immunopharmacol. 2020 Nov;88:106990.  [Content Brief]

    [5]. Koyama K, et al. Antinociceptive components of Ganoderma lucidum. Planta Med. 1997 Jun;63(3):224-7.  [Content Brief]

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