Cholesterol myristate (Synonyms: 胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate)

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Cholesterol myristate (Synonyms: 胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate) 纯度: ≥98.0%

Cholesterol myristate 是中药中天然类固醇。Cholesterol myristate 与多种离子通道结合，例如 nAChR，GABAA receptor 和内向整流钾离子通道 (potassium ion channel)。

Cholesterol myristate (Synonyms: 胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate)

Cholesterol myristate Chemical Structure

CAS No. : 1989-52-2

规格	价格	是否有货
250 mg	￥600	In-stock
500 mg		询价
1 g		询价

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Cholesterol myristate 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus

•同靶点产品:

•同靶点蛋白产品:

生物活性

Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel.

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate^[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cholesterol myristate 相关抗体:

分子量

597.01

Formula

C₄₁H₇₂O₂

CAS 号

1989-52-2

性状

固体

颜色

White to off-white

中文名称

胆固醇肉豆蔻酸

结构分类

Steroids

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

In Vitro:

Ethanol 中的溶解度 : 3.33 mg/mL (5.58 mM; 超声助溶)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6750 mL	8.3751 mL	16.7501 mL
5 mM	0.3350 mL	1.6750 mL	3.3500 mL
10 mM	—	—	—

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥98.0%

选择批次：

Data Sheet (596 KB) SDS (252 KB)

COA (186 KB) HNMR (276 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26. [Content Brief]

[2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42. [Content Brief]

[3]. Levitan I, et al. Cholesterol binding to ion channels. Front Physiol. 2014 Feb 26;5:65. [Content Brief]

Cell Assay ^[1]	MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26. [Content Brief] [2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42. [Content Brief] [3]. Levitan I, et al. Cholesterol binding to ion channels. Front Physiol. 2014 Feb 26;5:65. [Content Brief]

Cell Assay
^[1]

MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured^[1].