Beta-Sitosterol (purity>75%) (Synonyms: β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%))

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Beta-Sitosterol (purity>75%)  (Synonyms: β-Sitosterol (purity>75%); 22,23-Dihydrostigmasterol (purity>75%)) 纯度: ≥95.0%

Beta-Sitosterol (purity>75%) 是一种具有口服活性的植物甾醇。Beta-Sitosterol (purity>75%) 可干扰多种细胞信号通路，包括细胞周期，细胞凋亡 (apoptosis) 和细胞增殖。Beta-Sitosterol (purity>75%) 有抗炎、抗氧化和抗肿瘤活性。

Beta-Sitosterol (purity>75%) Chemical Structure

CAS No. : 83-46-5

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Beta-Sitosterol (purity>75%) 相关产品

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生物活性

Beta-Sitosterol (purity>75%) is a phytosterol with oral activity. Beta-Sitosterol (purity>75%) interferes with a variety of cell signaling pathways, including the cell cycle, apoptosis and cell proliferation. Beta-Sitosterol (purity>75%) has anti-inflammatory, antioxidant, and antitumor activities[1][2][3].

体外研究
(In Vitro)

Beta-Sitosterol purity>75% (16 μM, 1, 3, 5 天) 可抑制 MDA-MB-231 人乳腺癌细胞生长和诱导细胞凋亡[1]。
Beta-Sitosterol purity>75% (120, 240 μM, 24 h) 对 COLO 320 DM 细胞有明显的剂量依赖性生长抑制作用 (IC50 为 266.2 μM)。通过清除活性氧诱导细胞凋亡，抑制人结肠癌细胞中 β-catenin 和 PCNA 抗原的表达[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Beta-Sitosterol (purity>75%) 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 3 days
Result: No cytotoxicity at 16 μM

Apoptosis Analysis[1]

Cell Line: MDA-MB-231
Concentration: 16 μM
Incubation Time: 5 days
Result: Increased 33% apoptosis when assayed using 1×104 cells and a 6-fold increase in apoptosis when assayed using a smaller number of cells 5×103.

Western Blot Analysis[2]

Cell Line: COLO 320 DM
Concentration: 15, 30, 60, 120 μM
Incubation Time: 24 h
Result: Decreased β-catenin and PCNA expression.

体内研究
(In Vivo)

Beta-Sitosterol purity>75% (10-20 mg/kg, 混悬于 0.1% 的 CMC 中, 口服, 每天一次连续 16 周) 在结肠癌大鼠模型中具有预防癌变作用[2]。
Beta-Sitosterol purity>75% (10, 15, 20 mg/kg, 口服, 连续 21 天) 在链脲佐菌素 (HY-13753) 诱导的实验性高血糖大鼠模型中有抗高血糖和抗氧化作用[3]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon cancer rats model [2]
Dosage: 10, 20 mg/kg
Administration: p.o., suspended in 0.1% CMC (1.0 mL)
Result: Reduced the number of aberrant crypt and crypt multiplicity in a dose-dependent manner.
Animal Model: Streptozotocin-induced hyperglycemia rats model[3]
Dosage: 10, 15, 20 mg/kg
Administration: p.o.
Result: Increased insulin levels and decreased HbA1c levels.
Improved pancreatic antioxidant levels and decreased LPO levels.

分子量

414.71

Formula

C29H50O
CAS 号

83-46-5
性状

固体

颜色

White to off-white

结构分类
  • Steroids
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

Data Sheet (534 KB) SDS (393 KB)

COA (193 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Awad AB, et al. Inhibition of growth and stimulation of apoptosis by beta-sitosterol treatment of MDA-MB-231 human breast cancer cells in culture. Int J Mol Med. 2000 May;5(5):541-5.  [Content Brief]

    [2]. Baskar AA, et al. Chemopreventive potential of beta-Sitosterol in experimental colon cancer model–an in vitro and In vivo study. BMC Complement Altern Med. 2010 Jun 4;10:24.  [Content Brief]

    [3]. Gupta R, et al. Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia. J Diabetes. 2011 Mar;3(1):29-37.  [Content Brief]

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