12S-HHT (Synonyms: 12(S)-HHTrE)

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12S-HHT  (Synonyms: 12(S)-HHTrE) 纯度: ≥98.0%

12S-HHT (12(S)-HHTrE) 是前列腺素 H2 (PGH2) 的酶促产物，来源于环氧化酶 (COX) 介导的花生四烯酸代谢。12S-HHT 是 BLT2 的内源性配体，在体内完全激活 BLT2。12S-HHT 抑制紫外线诱导的角质形成细胞中 IL-6 的合成，发挥抗炎活性。

12S-HHT (Synonyms: 12(S)-HHTrE)

12S-HHT Chemical Structure

CAS No. : 54397-84-1

规格 价格 是否有货 数量
25μg（356.6 µM * 250 µL in Ethanol） ￥5200 In-stock

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生物活性

12S-HHT (12(S)-HHTrE) is an enzymatic product of prostaglandin H2 (PGH2) derived from cyclooxygenase (COX)-mediated arachidonic acid metabolism. 12S-HHT is an endogenous ligand for BLT2 that fully activates BLT2 in vivo. 12S-HHT suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity[1][2].

IC50 & Target

Human Endogenous Metabolite

 

BLT2

 

体外研究
(In Vitro)

12S-HHT (0-150 nM; 3 hours) has anti-inflammatory activity by attenuating the UVB-induced IL-6 synthesis in HaCaT cells[2].
12S-HHT inhibits the UVB-stimulated p38 MAPK/NF-κB pathway by up-regulating MKP-1, which leads to the suppression of IL-6 synthesis[2].
12S-HHT is an endogenous agonist for BLT2[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

12S-HHT 相关抗体:

Western Blot Analysis[2]

Cell Line: HaCaT cells
Concentration: 0, 12.5, 25, 75 or 150 nM
Incubation Time: 3 hours
Result: UVB (5 mJ/cm2) irradiation markedly up-regulated IL-6 synthesis and release, which was suppressed by the treatment with 12-HHT in a concentration-dependent manner.

分子量

280.40

Formula

C17H28O3
CAS 号

54397-84-1
性状

液体

颜色

Colorless to light yellow

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (533 KB) SDS (393 KB)

COA (183 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Saeki K, et al. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36.  [Content Brief]

    [2]. Lee JW, et al. 12(S)-Hydroxyheptadeca-5Z,8E,10E-trienoic acid suppresses UV-induced IL-6 synthesis in keratinocytes, exerting an anti-inflammatory activity. Exp Mol Med. 2012;44(6):378-386.  [Content Brief]

    [3]. Okuno T, et al. Metabolism and biological functions of 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid. Prostaglandins Other Lipid Mediat. 2021;152:106502.  [Content Brief]

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