Dihydrosanguinarine (Synonyms: 二氢血根碱; 13,14-Dihydrosanguinarine)

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Dihydrosanguinarine  (Synonyms: 二氢血根碱; 13,14-Dihydrosanguinarine) 纯度: 99.98%

二氢血根碱(Dihydrosanguinarine)是榕树叶片提取出的天然化合物，有抗真菌和抗增殖等活性报道。

Dihydrosanguinarine (Synonyms: 二氢血根碱; 13,14-Dihydrosanguinarine)

Dihydrosanguinarine Chemical Structure

CAS No. : 3606-45-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2970 In-stock
1 mg ￥966 In-stock
5 mg ￥2488 In-stock
10 mg ￥4738 In-stock
25 mg ￥7000 In-stock
50 mg ￥9355 In-stock
100 mg   询价  
200 mg   询价  

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Dihydrosanguinarine 相关产品

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生物活性

Dihydrosanguinarine is a natural compound isolated from the leaves of Macleaya microcarpa; has antifungal and anticancer activity. IC50 value: Target: in vitro: Dihydrosanguinarine showed much less cytotoxicity than sanguinarine: at the highest concentration tested (20 microM) and 24h exposure, dihydrosanguinarine decreased viability only to 52% [1]. Dihydrosanguinarine showed the highest antifungal activity against B. cinerea Pers, with 95.16% mycelial growth inhibition at 50 μg/ml [2]. dihydrosanguinarine showed the most potent leishmanicidal activities (IC(50) value: 0.014 microg/ml, respectively) [4]. in vivo: Repeated dosing of DHSG for 90 days at up to 500 ppm in the diet (i.e. approximately 58 mg/kg/day) showed no evidence of toxicity in contrast to results published in the literature [3].

分子量

333.34

Formula

C20H15NO4
CAS 号

3606-45-9
性状

固体

颜色

Off-white to light yellow

中文名称

二氢血根碱
结构分类
  • Alkaloids
  • Quinoline Alkaloids
初始来源
  • 植物
  • 罂粟科
  • 博落回
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5.2 mg/mL (15.60 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9999 mL 14.9997 mL 29.9994 mL
5 mM 0.6000 mL 2.9999 mL 5.9999 mL
10 mM 0.3000 mL 1.5000 mL 2.9999 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

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浓度

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体积

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

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浓度 (final)

C2

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体积 (final)

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动物溶解方案

动物溶解方案计算器
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给药剂量

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工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.98%

Data Sheet (599 KB) SDS (392 KB)

COA (194 KB) HNMR (257 KB) LCMS (99 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Vrba J, et al. Cytotoxic activity of sanguinarine and dihydrosanguinarine in human promyelocytic leukemia HL-60 cells. Toxicol In Vitro. 2009 Jun;23(4):580-8.  [Content Brief]

    [2]. Feng G, et al. Inhibitory activity of dihydrosanguinarine and dihydrochelerythrine against phytopathogenic fungi. Nat Prod Res. 2011 Jul;25(11):1082-9.  [Content Brief]

    [3]. Vrublova E, et al. The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study. Food Chem Toxicol. 2008 Jul;46(7):2546-53.  [Content Brief]

    [4]. Fuchino H, et al. In vitro leishmanicidal activity of benzophenanthridine alkaloids from Bocconia pearcei and related compounds. Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1047-50.  [Content Brief]

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