Khellin (Synonyms: 呋喃并色酮)

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Khellin  (Synonyms: 呋喃并色酮) 纯度: 99.89%

Khellin 是一种呋喃并色酮，能从 Ammi visnuga L. 中提取得到。Khellin 是一种 EGFR 抑制剂，其 IC50 为 0.15 µM。Khelline 在体外具有抗增殖活性。Khellin 具有抗痉挛和冠状动脉舒张作用。

Khellin (Synonyms: 呋喃并色酮)

Khellin Chemical Structure

CAS No. : 82-02-0

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生物活性

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects[1][2].

IC50 & Target

IC50: 0.15 µM (EGFR)[1]
体外研究
(In Vitro)

Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells[1].
Khellin inhibits the pathways of Ca2+ influx which are activated by both noradrenaline and high K+[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Khellin 相关抗体:
分子量

260.24

Formula

C14H12O5
CAS 号

82-02-0
性状

固体

颜色

White to light yellow

中文名称

呋喃并色酮
结构分类
  • Phenylpropanoids
  • Lignans
初始来源
  • 植物
  • 菊科
  • 银沙蒿
  • 植物
  • 伞形科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 16.67 mg/mL (64.06 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.8426 mL 19.2130 mL 38.4261 mL
5 mM 0.7685 mL 3.8426 mL 7.6852 mL
10 mM 0.3843 mL 1.9213 mL 3.8426 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

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体积

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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

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动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.89%

Data Sheet (604 KB) SDS (419 KB)

COA (270 KB) HNMR (244 KB) LCMS (91 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Abdel-Sattar S Hamad Elgazwy, et al. Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibitors. J Enzyme Inhib Med Chem. 2013 Dec;28(6):1171-81.  [Content Brief]

    [2]. A Ubeda, et al. Relaxant actions of khellin on vascular smooth muscle. J Pharm Pharmacol . 1989 Apr;41(4):236-41.  [Content Brief]

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