Cytochalasin E (Synonyms: 细胞松弛素E)

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Cytochalasin E  (Synonyms: 细胞松弛素E) 纯度: 99.90%

Cytochalasin E 是一种含有曲霉衍生真菌代谢产物的环氧化物，抑制血管生成和肿瘤生长，Cytochalasin E 是一种有效的肌动蛋白解聚剂，能结合肌动蛋白丝的倒刺端并盖住，以防止肌动蛋白伸长。

Cytochalasin E (Synonyms: 细胞松弛素E)

Cytochalasin E Chemical Structure

CAS No. : 36011-19-5

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1 mg ￥2900 In-stock
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Cytochalasin E 相关产品

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  • Bioactive Compound Library Plus

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生物活性

Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2].

体外研究
(In Vitro)

Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3].
Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cytochalasin E 相关抗体:
分子量

495.56

Formula

C28H33NO7
CAS 号

36011-19-5
性状

固体

颜色

White to off-white

中文名称

细胞松弛素E
结构分类
  • Alkaloids
  • Pyrrole Alkaloids
初始来源
  • 微生物

the fungus R. necatrix
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.90%

Data Sheet (536 KB) SDS (251 KB)

COA (272 KB) RP-HPLC (916 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7.  [Content Brief]

    [2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83.  [Content Brief]

    [3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647.  [Content Brief]

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