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Isatin (Synonyms: Indoline-2,3-dione) 纯度: 99.89%
Isatin (Indoline-2,3-dione) 是单胺氧化酶 (MAO)的有效抑制剂,IC50 为3 μM。 也与中枢苯二氮卓受体结合 (对抗氯硝西泮IC50=123 μM)。 还充当心房钠尿肽刺激和一氧化氮刺激的鸟苷酸环化酶拮抗剂。 对5-羟色胺系统有影响。
Isatin Chemical Structure
CAS No. : 91-56-5
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1 – 0.2 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥110 | In-stock | |
500 mg | ¥100 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
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生物活性 |
Isatin (Indoline-2,3-dione) is a potent inhibitor of monoamine oxidase (MAO) with an IC50 of 3 μM. Also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 μM)[1]. Also acts as an antagonist of both atrial natriuretic peptide stimulated and nitric oxide-stimulated guanylate cyclase activity[2]. Shows effect on the serotonergic system[3]. |
IC50 & Target |
IC50: 3 μM (MAO B)[1] |
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体外研究 (In Vitro) |
In dopaminergic SH-SY5Y cells isatin (1-400 μM) induces cell death in dose- and time dependent manner. This death occurred as a continuum of survival, apoptosis and necrosis[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
A single dose of isatin (80 mg/kg) has a rapid effect on the serotonergic system in the hypothalamus. Isatin significantly increases 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
147.13 |
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Formula |
C8H5NO2 |
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CAS 号 |
91-56-5 |
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性状 |
固体 |
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颜色 |
Orange to red |
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中文名称 |
靛红;吲哚-2,3-二酮 |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 100 mg/mL (679.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) H2O 中的溶解度 : < 0.1 mg/mL (insoluble) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
In Vivo:
请根据您的 实验动物和给药方式 选择适当的溶解方案。 以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
请输入您的动物体内配方组成:
%
DMSO + %
%
Tween-80 + %
Saline 如果您的动物是免疫缺陷鼠或者体弱鼠,建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。 方案所需 助溶剂 包括:DMSO, ,均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。 ,Tween 80,均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL DMSO(母液浓度为 mg/mL)。
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E-mail:sales@jinpanbio.com 技术支持电话:021-50837765 技术支持邮箱:sales@jinpanbio.com 动物实验体内工作液的配制方法 : 取 μL DMSO 储备液,加入 μL 。 μL ,混合均匀至澄清,再加 μL Tween 80,混合均匀至澄清,再加 μL 生理盐水。
连续给药周期超过半月以上,请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态,从左到右依次添加助溶剂。您可采用超声加热 (超声清洗仪,建议频次 20-40 kHz),涡旋吹打等方式辅助溶解。
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纯度 & 产品资料 |
纯度: 99.89%
Data Sheet (622 KB) SDS (393 KB)
COA (197 KB) HNMR (129 KB) RP-HPLC (261 KB) LCMS (111 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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