Vasicinone (Synonyms: (-)-Vasicinone)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Vasicinone (Synonyms: (-)-Vasicinone) 纯度: 99.83%

Vasicinone 是从鸭嘴花中分离得到的喹唑啉类生物碱。Vasicinone 是一种潜在的研究帕金森病和其他氧化应激相关神经退行性疾病的化合物。

Vasicinone Chemical Structure

CAS No. : 486-64-6

规格	价格	是否有货
1 mg	￥1300	In-stock
5 mg	￥3900	In-stock
10 mg		询价
50 mg		询价

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Vasicinone 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Natural Product Library
Anti-Aging Compound Library
Oxygen Sensing Compound Library
Alkaloids Library
Anti-Parkinson’s Disease Compound Library
Neurodegenerative Disease-related Compound Library
Plant-Sourced Natural Product Library
Human Metabolite Library

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生物活性

Vasicinone is a quinazoline alkaloid isolated from the Adhatoda vasica. Vasicinone is a potential agent for Parkinson’s disease and possibly other oxidative stress-related neurodegenerative disorders^[1].

体外研究
(In Vitro)

Vasicinone (1~30 µM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability^[1].
Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death^[1].
Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Vasicinone 相关抗体:

Cell Viability Assay^[1]

Cell Line:	SH-SY5Y cells
Concentration:	1~30 µM
Incubation Time:	24 hours
Result:	Significantly reversed the paraquat-induced reduction in cell viability.

Western Blot Analysis^[1]

Cell Line:	SH-SY5Y cells
Concentration:	10 and 15 µM
Incubation Time:	24 hours
Result:	Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway.

Apoptosis Analysis^[1]

Cell Line:	SH-SY5Y cells
Concentration:	10 and 15 µM
Incubation Time:	24 hours
Result:	Dose-dependently reduced the percentage of apoptotic cells.

分子量

202.21

Formula

C₁₁H₁₀N₂O₂

CAS 号

486-64-6

性状

固体

颜色

White to off-white

结构分类

Alkaloids
Pyrrole Alkaloids

初始来源

植物
爵床科
鸭嘴花

植物
其他科

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO 中的溶解度 : 50 mg/mL (247.27 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.9454 mL	24.7268 mL	49.4535 mL
5 mM	0.9891 mL	4.9454 mL	9.8907 mL
10 mM	0.4945 mL	2.4727 mL	4.9454 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.83%

选择批次：

Data Sheet (603 KB) SDS (251 KB)

COA (175 KB) HNMR (253 KB) LCMS (88 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Ju DT, et al. Effect of Vasicinone against Paraquat-Induced MAPK/p53-Mediated Apoptosis via the IGF-1R/PI3K/AKT Pathway in a Parkinson’s Disease-Associated SH-SY5Y Cell Model. Nutrients. 2019;11(7):1655. Published 2019 Jul 19. [Content Brief]

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Vasicinone 相关产品

•相关化合物库:

•同靶点产品:

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Vasicinone 相关抗体:

摩尔计算器

稀释计算器