Cercosporin (Synonyms: 尾孢菌素)

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Cercosporin  (Synonyms: 尾孢菌素) 纯度: ≥98.0%

Cercosporin 由植物病原体 Pseudocercosporella capsellae产生。Cercosporin 是一种有效的光敏剂，具有短的活化波长，主要适用于表面 PDT 光动力研究 (尤其适用于避免穿孔的研究)。Cercosporin 是 PKC 的抑制剂，含有 PKC 活性所必需的醌结构特征, 其 IC50=0.6-1.3 μM。

Cercosporin (Synonyms: 尾孢菌素)

Cercosporin Chemical Structure

CAS No. : 35082-49-6

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Cercosporin 相关产品

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生物活性

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].

IC50 & Target

IC50: 0.6-1.3 μM (PKC)[2]
体外研究
(In Vitro)

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cercosporin 相关抗体:

Cell Viability Assay[1]

Cell Line: Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
Concentration: 0 μM, 1 μM, 2 μM, 3 μM
Incubation Time: 24 hours
Result: Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

分子量

534.51

Formula

C29H26O10
CAS 号

35082-49-6
性状

固体

颜色

Brown to reddish brown

中文名称

尾孢菌素
结构分类
  • Phenols
  • Polyphenols
  • Others
初始来源
  • 微生物

Pseudocercosporella capsellae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 10 mg/mL (18.71 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8709 mL 9.3544 mL 18.7087 mL
5 mM 0.3742 mL 1.8709 mL 3.7417 mL
10 mM 0.1871 mL 0.9354 mL 1.8709 mL

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储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (614 KB) SDS (251 KB)

COA (277 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396.  [Content Brief]

    [2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25.  [Content Brief]

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