Neocryptotanshinone (Synonyms: 新隐丹参酮)

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Neocryptotanshinone  (Synonyms: 新隐丹参酮) 纯度: 98.82%

Neocryptotanshinone 是从丹参 (Salvia Miltiorrhiza) 分离得到的一种丹参二萜，通过抑制 NF-κB 和 iNOS 信号来抑制脂多糖 (LPS) 诱导的炎症。

Neocryptotanshinone (Synonyms: 新隐丹参酮)

Neocryptotanshinone Chemical Structure

CAS No. : 109664-02-0

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5 mg ￥2800 In-stock
10 mg ￥5000 In-stock
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生物活性

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

IC50 & Target

iNOS

 

体外研究
(In Vitro)

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways[1].
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells[1].
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Neocryptotanshinone 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW264.7 cells
Concentration: 5, 10 and 20 μM
Incubation Time: 24 hours
Result: Inhibited LPS-induced cell viability in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 20 μM
Incubation Time: 24 hours
Result: Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.

体内研究
(In Vivo)

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MSU-induced pain model in male ICR mice (weighing 20-25 g)[2]
Dosage: 10, 25, 50 or 100 mg/kg
Administration: Oral gavage; for 30, 60, 120 min
Result: Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

分子量

314.38

Formula

C19H22O4
CAS 号

109664-02-0
性状

固体

颜色

Light yellow to yellow

中文名称

新隐丹参酮
结构分类
  • Terpenoids
  • Diterpenoids
  • Quinones
  • Naphthalene Quinones
初始来源
  • 植物
  • 豆科
  • 雨树
  • 植物
  • 唇形科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (318.09 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1809 mL 15.9043 mL 31.8086 mL
5 mM 0.6362 mL 3.1809 mL 6.3617 mL
10 mM 0.3181 mL 1.5904 mL 3.1809 mL

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* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

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动物溶解方案

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给药剂量

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计算结果
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纯度 & 产品资料

纯度: 98.82%

Data Sheet (603 KB) SDS (251 KB)

COA (264 KB) HNMR (154 KB) RP-HPLC (244 KB) MS (78 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5(4):323-9.  [Content Brief]

    [2]. H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64(5):648-50.  [Content Brief]

    [3]. FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41(2): 219-226.  [Content Brief]

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