上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Lucidin (Synonyms: 卢西定; NSC 30546) 纯度: 97.02%
Lucidin (NSC 30546)是茜草中的天然成分,能诱导细菌和哺乳动物细胞的突变。
Lucidin Chemical Structure
CAS No. : 478-08-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥2310 | In-stock | |
5 mg | ¥2100 | In-stock | |
10 mg | ¥3400 | In-stock | |
25 mg | ¥6300 | In-stock | |
50 mg | ¥9800 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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生物活性 |
Lucidin (NSC 30546) is a natural component of Rubia cordifolia. lucidin is mutagenic in bacteria and mammalian cells. IC50 Value: Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3′-phosphate with lucidin [2]. in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2]. Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2]. Clinical trial: |
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分子量 |
270.24 |
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Formula |
C15H10O5 |
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CAS 号 |
478-08-0 |
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性状 |
固体 |
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颜色 |
Light yellow to yellow |
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中文名称 |
光泽汀;光泽定;卢西定 |
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结构分类 |
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初始来源 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 6.67 mg/mL (24.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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纯度 & 产品资料 |
纯度: 97.02%
Data Sheet (600 KB) SDS (418 KB)
COA (194 KB) HNMR (248 KB) LCMS (283 KB) 产品使用指南 (1538 KB) |
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参考文献 |
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