Lucidin (Synonyms: 卢西定; NSC 30546)

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Lucidin  (Synonyms: 卢西定; NSC 30546) 纯度: 97.02%

Lucidin (NSC 30546)是茜草中的天然成分，能诱导细菌和哺乳动物细胞的突变。

Lucidin (Synonyms: 卢西定; NSC 30546)

Lucidin Chemical Structure

CAS No. : 478-08-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2310 In-stock
5 mg ￥2100 In-stock
10 mg ￥3400 In-stock
25 mg ￥6300 In-stock
50 mg ￥9800 In-stock
100 mg   询价  
200 mg   询价  

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生物活性

Lucidin (NSC 30546) is a natural component of Rubia cordifolia. lucidin is mutagenic in bacteria and mammalian cells. IC50 Value: Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3′-phosphate with lucidin [2]. in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2]. Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2]. Clinical trial:

分子量

270.24

Formula

C15H10O5
CAS 号

478-08-0
性状

固体

颜色

Light yellow to yellow

中文名称

光泽汀；光泽定；卢西定
结构分类
  • Quinones
  • Anthraquinones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 茜草科
  • 茜草
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 6.67 mg/mL (24.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7004 mL 18.5021 mL 37.0041 mL
5 mM 0.7401 mL 3.7004 mL 7.4008 mL
10 mM 0.3700 mL 1.8502 mL 3.7004 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 97.02%

Data Sheet (600 KB) SDS (418 KB)

COA (194 KB) HNMR (248 KB) LCMS (283 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Westendorf J, et al. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol. 1988 Jun;4(2):225-39.  [Content Brief]

    [2]. Westendorf J, et al. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis. 1998 Dec;19(12):2163-8.  [Content Brief]

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