Quassin (Synonyms: Nigakilactone D)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Quassin  (Synonyms: Nigakilactone D) 纯度: ≥98.0%

Quassin (Nigakilactone D) 是一种从 Quassia amara 的茎皮提取物中提取的生物活性三萜。Quassin 抑制 P. falciparum，IC50 为 0.15 μM。Quassin 具有可逆的避育能力，抗雌激素和抗疟原虫活性。

Quassin (Synonyms: Nigakilactone D)

Quassin Chemical Structure

CAS No. : 76-78-8

规格 价格 是否有货 数量
1 mg ￥900 In-stock
5 mg ￥3600 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Quassin 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Natural Product Library
  • Covalent Screening Library
  • Lipid Compound Library
  • Endocrinology Compound Library
  • Medicine Food Homology Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Active Compound Library
  • Antiparasitic Compound library
  • Plant-Sourced Natural Product Library
  • Heterocyclic Compound Library

•同靶点产品:

•同靶点蛋白产品:

生物活性

Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].

IC50 & Target

IC50: 0.15 μM (P. falciparum)[2]
体外研究
(In Vitro)

Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Quassin 相关抗体:
体内研究
(In Vivo)

Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 35 females albino rats (150-170 g)[1]
Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg
Administration: Oral administration; daily; for 60 days
Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats.

分子量

388.45

Formula

C22H28O6
CAS 号

76-78-8
性状

固体

颜色

White to off-white

中文名称

苦楝树甙,苦木素
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 苦木科
  • 苦木
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (546 KB) SDS (392 KB)

COA (199 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Raji Y, et al. Reproductive activities of female albino rats treated with quassin, a bioactive triterpenoid from stem bark extract of Quassia amara. Niger J Physiol Sci. 2010 Nov 24;25(2):95-102.  [Content Brief]

    [2]. Mishra K, et al. Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisinin. Exp Parasitol. 2010 Apr;124(4):421-7.  [Content Brief]

    [3]. Njar VC, et al. Antifertility activity of Quassia amara: quassin inhibits the steroidogenesis in rat Leydig cells in vitro. Planta Med. 1995 Apr;61(2):180-2.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务