Rubropunctatin

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Rubropunctatin  纯度: ≥98.0%

Rubropunctatin 是一种从红曲霉发酵米(红霉米)提取物中分离出来的橙色的氮杂酮类色素。 Rubropunctatin 具有抗炎，免疫抑制和抗氧化作用，还具有抗肿瘤活性。

Rubropunctatin

Rubropunctatin Chemical Structure

CAS No. : 514-67-0

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1 mg ￥4100 In-stock
2 mg ￥7200 In-stock
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生物活性

Rubropunctatin, an orange azaphilone pigment, is isolated from the extracts of Monascus pilosus-fermented rice (red-mold rice). Rubropunctatin has anti-inflammatory, immunosuppressive and antioxidative effects, and also exhibits anti-tumor activity[1][2][3].

体外研究
(In Vitro)

Rubropunctatin (1.5-30 μM; 24 h) shows selective tumoricidal effect on the human gastric carcinoma BGC-823 cells and no significant toxicity toward normal epithelial cell GES-1[1].
Rubropunctatin (5-30 μM; 6-24 h) induces apoptosis in a dose- and time-dependent manner in BGC-823 cells[1].
Rubropunctatin (0.75-8.0 µg/ml) exhibits DDPH radical scavenging activity, inhibition of super oxide radical generation and ferric reducing activity[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Rubropunctatin 相关抗体:

Cell Viability Assay[1]

Cell Line: BGC-823 and GES-1cells
Concentration: 1.5, 3, 6, 12, 15, 18, 30 μM
Incubation Time: 24 hours
Result: Decreased the viability of BGC-823 cells with an IC50 of 12.57 μM for 24 h.
Did not show obvious cytotoxic effects on the normal cells.

Cell Cycle Analysis[1]

Cell Line: BGC-823 cells
Concentration: 0, 5, 10, 30 μM
Incubation Time: 0, 6, 12, 24 hours
Result: Increased the percentage of cells in sub-G1 phase in a dose- and time-dependent manner.

体内研究
(In Vivo)

Rubropunctatin (8-32 mg/kg; i.v. for 5 times) has anti-tumor effect mice[1].
Rubropunctamine inhibits 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice, with an ID50 of 0.11 mg/ear[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (5 weeks) are inoculated with BGC-823 cells[1]
Dosage: 8, 32 mg/kg
Administration: I.v. five times (day 1st, 4th, 7th, 10th, and 13th)
Result: Diminished the tumor volume by 11.1% (8 mg/kg) and 24.2% (32 mg/kg).
Reduced the tumor weight by 23.5% (8 mg/kg) and 37.7% (32 mg/kg).
No significant difference was observed on the body weight.

分子量

354.40

Formula

C21H22O5
CAS 号

514-67-0
性状

固体

颜色

Yellow to orange

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 微生物

Monascus purpureus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (532 KB) SDS (251 KB)

COA (264 KB) HNMR (272 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Zheng Y, et, al. Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Appl Microbiol Biotechnol. 2010 Nov;88(5):1169-77.  [Content Brief]

    [2]. Dhale MA, et, al. Protective and antioxidative effect of rubropunctatin against oxidative protein damage induced by metal catalyzed reaction. Int J Biol Macromol. 2018 Sep;116:409-416.  [Content Brief]

    [3]. Akihisa T, et, al. Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects. J Agric Food Chem. 2005 Feb 9;53(3):562-5.  [Content Brief]

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