Glychionide A (Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

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Glychionide A  (Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷) 纯度: 99.47%

Glychionide A 是一种黄酮苷，存在于 Glychirriza glabra 的根中。Glychionide A 促进 PANC-1 胰腺癌细胞的凋亡和自噬。Glychionide A 可用于癌症的研究。

Glychionide A (Synonyms: 去甲汉黄芩素-7-O-葡萄糖醛酸苷)

Glychionide A Chemical Structure

CAS No. : 119152-50-0

规格 价格 是否有货 数量
1 mg ￥1400 In-stock
5 mg ￥4200 In-stock
10 mg ￥6510 In-stock
50 mg   询价  
100 mg   询价  

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Glychionide A 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Autophagy Compound Library
  • Glycoside Compound Library
  • Lipid Compound Library
  • Phenols Library
  • Flavonoids Library
  • Anti-Pancreatic Cancer Compound Library
  • Anti-Cancer Natural Product Library
  • Plant-Sourced Natural Product Library
  • Cell Death Library

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生物活性

Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1].
Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1].
Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Glychionide A 相关抗体:
分子量

446.36

Formula

C21H18O11
CAS 号

119152-50-0
性状

固体

颜色

Light yellow to yellow

中文名称

去甲汉黄芩素-7-O-葡萄糖醛酸苷
结构分类
  • Flavonoids
  • Flavones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.47%

Data Sheet (527 KB) SDS (251 KB)

COA (265 KB) HNMR (196 KB) CNMR (183 KB) RP-HPLC (427 KB) MS (484 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.  [Content Brief]

    [2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb  [Content Brief]

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