Rubiadin-1-methyl ether

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Rubiadin-1-methyl ether  纯度: 98.89%

Rubiadin-1-methyl ether 是巴戟天中的蒽醌类化合物，可抑制破骨细胞性骨吸收，通过抑制 NF-κB p65 磷酸化水平，降解 IκBα 蛋白，以及降低 p65 的核转位起作用。

Rubiadin-1-methyl ether

Rubiadin-1-methyl ether Chemical Structure

CAS No. : 7460-43-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥5500 In-stock
1 mg ￥2000 In-stock
5 mg ￥5000 In-stock
10 mg ￥7750 In-stock
50 mg   询价  
100 mg   询价  

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Rubiadin-1-methyl ether 相关产品

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生物活性

Rubiadin-1-methyl ether is a natural anthraquinone isolated from Morinda officinalis How, and inhibits osteoclastic bone resorption via inhibition on the phosphorylation of NF-κB p65 and the degradation of IκBα as well as decrease in the nuclear translocation of p65[1].

IC50 & Target[1]

p65

 

分子量

268.26

Formula

C16H12O4
CAS 号

7460-43-7
性状

固体

颜色

Light yellow to yellow

结构分类
  • Quinones
  • Anthraquinones
  • Phenols
  • Monophenols
初始来源
  • 植物
  • 茜草科
  • 茜草
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 125 mg/mL (465.97 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7277 mL 18.6386 mL 37.2773 mL
5 mM 0.7455 mL 3.7277 mL 7.4555 mL
10 mM 0.3728 mL 1.8639 mL 3.7277 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

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动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.89%

Data Sheet (601 KB) SDS (392 KB)

COA (267 KB) HNMR (243 KB) LCMS (266 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. He YQ, et al. Rubiadin-1-methyl ether from Morinda officinalis How. Inhibits osteoclastogenesis through blocking RANKL-induced NF-κB pathway. Biochem Biophys Res Commun. 2018 Dec 2;506(4):927-931.  [Content Brief]

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