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11-Beta-hydroxyandrostenedione (Synonyms: 4-Androsten-11β-ol-3,17-dione) 纯度: 98.09%
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。
11-Beta-hydroxyandrostenedione Chemical Structure
CAS No. : 382-44-5
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| 10 mM * 1 mL in DMSO | ￥550 | In-stock | |
| 5 mg | ￥500 | In-stock | |
| 10 mg | ￥800 | In-stock | |
| 25 mg | ￥1600 | In-stock | |
| 50 mg | ￥2560 | In-stock | |
| 100 mg | 询价 | ||
| 200 mg | 询价 |
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11-Beta-hydroxyandrostenedione 相关产品
•相关化合物库:
- Natural Product Library Plus
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- Natural Product Library
- Human Endogenous Metabolite Compound Library
- Lipid Compound Library
- Endocrinology Compound Library
- Food-Sourced Compound Library
- Human Metabolite Library
- Metabolic Enzyme Compound Library
- Cysteine Targeted Covalent Library
- Animal-Sourced Natural Product Library
| 生物活性 |
11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism[1][2]. |
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| IC50 & Target[1] |
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| 体外研究 (In Vitro) |
In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 体内研究 (In Vivo) |
The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushing’s syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
302.41 |
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| Formula |
C19H26O3 |
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| CAS 号 |
382-44-5 |
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| 性状 |
固体 |
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| 颜色 |
White to off-white |
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| 结构分类 |
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| 初始来源 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 100 mg/mL (330.68 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO) 配制储备液
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
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给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
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| 纯度 & 产品资料 |
纯度: 99.74%
Data Sheet (606 KB) SDS (420 KB)
COA (177 KB) LCMS (95 KB) 产品使用指南 (1538 KB) |
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| 参考文献 |
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