Sterculic acid (Synonyms: 苹婆酸)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Sterculic acid  (Synonyms: 苹婆酸) 纯度: ≥98.0%

Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 特异性抑制 delta-9 去饱和酶 (Δ9D) 活性，IC50 值为 0.9 μM。

Sterculic acid (Synonyms: 苹婆酸)

Sterculic acid Chemical Structure

CAS No. : 738-87-4

规格 价格 是否有货 数量
25 mg ￥9000 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Sterculic acid 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

•同靶点产品:

•同靶点蛋白产品:

生物活性

Sterculic acid is a stearoyl-CoA desaturase-1 (SCD1) inhibitor. Sterculic acid specifically inhibits the delta-9 desaturase (Δ9D) activity with an IC50 value of 0.9 μM[1].

IC50 & Target[1]

delta-9 desaturase

0.9 μM (IC50)

体外研究
(In Vitro)

Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities[2].
Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2].
Sterculic acid is also able to mediate anti-inflammatory and protective effects[2].
Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Sterculic acid 相关抗体:
体内研究
(In Vivo)

Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1) in vivo[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

294.47

Formula

C19H34O2
CAS 号

738-87-4
性状

液体

颜色

Colorless to light yellow

中文名称

苹婆酸
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 植物
  • 梧桐科
  • 香苹婆
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Methanol 中的溶解度 : 10 mg/mL (33.96 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3959 mL 16.9797 mL 33.9593 mL
5 mM 0.6792 mL 3.3959 mL 6.7919 mL
10 mM 0.3396 mL 1.6980 mL 3.3959 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (591 KB) SDS (251 KB)

COA (159 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Lei Zhang, et al. A multiplexed cell assay in HepG2 cells for the identification of delta-5, delta-6, and delta-9 desaturase and elongase inhibitors. J Biomol Screen. 2010 Feb;15(2):169-76.  [Content Brief]

    [2]. Rafael Peláez, et al. Sterculic Acid: The Mechanisms of Action beyond Stearoyl-CoA Desaturase Inhibition and Therapeutic Opportunities in Human Diseases. Cells. 2020 Jan 7;9(1):140.  [Content Brief]

    [3]. Abril Ramírez-Higuera, et al. Preventive Action of Sterculic Oil on Metabolic Syndrome Development on a Fructose-Induced Rat Model. J Med Food. 2020 Mar;23(3):305-311.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务