1-Hydroxyanthraquinone (Synonyms: 1-羟基蒽醌)

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1-Hydroxyanthraquinone (Synonyms: 1-羟基蒽醌) 纯度: 98.77%

1-Hydroxyanthraquinone 是具有口服活性的天然产物，可来源于一些植物如 Tabebuia avellanedae，具有致癌作用。

1-Hydroxyanthraquinone Chemical Structure

CAS No. : 129-43-1

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生物活性

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect^[1].

体内研究
(In Vivo)

1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Thirty rats^[1].
Dosage:	1% HA in diet.
Administration:	Diet.
Result:	Associated with decreased weight gain which was particularly marked towards the termination of experiment. One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon. Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days. A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g).

分子量

224.21

Formula

C₁₄H₈O₃

CAS 号

129-43-1

性状

固体

颜色

Yellow to orange

中文名称

1-羟基蒽醌

结构分类

Quinones
Anthraquinones

Phenols
Monophenols

初始来源

植物
其他科

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO 中的溶解度 : 16.67 mg/mL (74.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4601 mL	22.3005 mL	44.6010 mL
5 mM	0.8920 mL	4.4601 mL	8.9202 mL
10 mM	0.4460 mL	2.2301 mL	4.4601 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.77%

选择批次：

Data Sheet (600 KB) SDS (393 KB)

COA (270 KB) HNMR (253 KB) LCMS (99 KB)

产品使用指南 (1538 KB)

参考文献

[1]. H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. [Content Brief]

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摩尔计算器

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