Meleagrin

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Meleagrin  纯度: ≥99.0%

Meleagri 是由青霉属 (Penicillium) 真菌产生的具有抗微生物和抗增殖活性的罗奎福汀 C 衍生生物碱。Meleagrin 是一类 FabI 抑制剂。Meleagri 是一种主要的 c-Met 抑制实体，有助于控制 c-Met 依赖性转移和侵袭性乳腺癌。

Meleagrin

Meleagrin Chemical Structure

CAS No. : 71751-77-4

规格 价格 是否有货 数量
1 mg ￥2300 In-stock
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Meleagrin 相关产品

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  • Natural Product Library Plus
  • Bioactive Compound Library Plus

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生物活性

Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies[1][2][3].

体外研究
(In Vitro)

Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3].
Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Meleagrin 相关抗体:
体内研究
(In Vivo)

Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

433.46

Formula

C23H23N5O4
CAS 号

71751-77-4
性状

固体

颜色

Off-white to light yellow

结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 微生物

marine fungus Emericella dentata Nq45
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (540 KB) SDS (251 KB)

COA (278 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Newmister SA, et al. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosyntheticpathway. Org Biomol Chem. 2018 Sep 11;16(35):6450-6459.  [Content Brief]

    [2]. Zheng CJ, et al. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action. PLoS One. 2013 Nov 28;8(11):e78922.  [Content Brief]

    [3]. Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15;24(2):113-22.  [Content Brief]

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