Phenylephrine-d3 hydrochloride(Synonyms: (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride)

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Phenylephrine-d3 hydrochloride (Synonyms: (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride)

Phenylephrine-d3 (R)-(-)-Phenylephrine-d3) hydrochloride 是 Phenylephrine hydrochloride 的氘代物。(R)-(-)-Phenylephrine hydrochloride是一种选择性的α1-肾上腺素能受体激动剂，对α1D，α1B 和α1A 受体的pKis 分为5.86，4.87和4.70。

Phenylephrine-d3 hydrochloride(Synonyms: (R)-(-)-Phenylephrine-d3 hydrochloride; L-Phenylephrine-d3 hydrochloride)

Phenylephrine-d3 hydrochloride Chemical Structure

CAS No. : 1217858-50-8

规格 价格 是否有货
5 mg ￥19500 询问价格 & 货期

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生物活性

Phenylephrine-d3 (R)-(-)-Phenylephrine-d3) hydrochloride is the deuterium labeled Phenylephrine hydrochloride. (R)-(-)-Phenylephrine hydrochloride is a selective α1-adrenoceptor agonist with pKis of 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

206.68

Formula

C9H11D3ClNO2
CAS 号

1217858-50-8
中文名称

盐酸去氧肾上腺素 d3 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Ford AP, et al. Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications foralpha1-adrenoceptor classification. Br J Pharmacol. 1997 Jul;121(6):1127-35.

    [3]. Minneman KP, et al. Selectivity of agonists for cloned alpha 1-adrenergic receptor subtypes. Mol Pharmacol. 1994 Nov;46(5):929-36.

    [4]. Wang J, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway. Front Biosci (Landmark Ed). 2016 Jan 1;21:502-13.

    [5]. Lazou A, et al. Activation of mitogen-activated protein kinases (p38-MAPKs, SAPKs/JNKs and ERKs) by the G-protein-coupled receptor agonist phenylephrine in the perfused rat heart. Biochem J. 1998 Jun 1;332 ( Pt 2):459-65.

    [6]. Li NJ, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury. Chin Med Sci J. 2013 Mar;28(1):1-6.

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