Lenampicillin-d5 hydrochloride(Synonyms: 盐酸仑氨苄西林 d5 (盐酸盐))

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Lenampicillin-d5 hydrochloride (Synonyms: 盐酸仑氨苄西林 d5 (盐酸盐))

Lenampicillin-d5 hydrochloride 是 Lenampicillin hydrochloride 的氘代物。Lenampicillin hydrochloride (KBT 1585 hydrochloride) 是氨苄西林的口服前药，是一种有效的-内酰胺类抗菌(beta-lactam antibacterial) 剂，可抑制细菌的青霉素结合蛋白(转肽酶)。与氨苄西林相比，Lenampicillin 有改善吸收、减少副作用的作用，并应用于化脓性皮肤软组织感染的研究。

Lenampicillin-d5 hydrochloride(Synonyms: 盐酸仑氨苄西林 d5 (盐酸盐))

Lenampicillin-d5 hydrochloride Chemical Structure

CAS No. : 1356847-85-2

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生物活性

Lenampicillin-d5 (KBT 1585-d5) hydrochloride is the deuterium labeled Lenampicillin hydrochloride. Lenampicillin hydrochloride (KBT 1585 hydrochloride) is an orally active prodrug of Ampicillin and is an effective beta-lactam antibacterial agent that inhibits bacterial penicillin-binding proteins (transpeptidase). Lenampicillin hydrochloride has improved absorption and decreased side effects compares to Ampicillin and is applied in the investigation of the suppurative skin and soft tissue infection[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

502.98

Formula

C21H19D5ClN3O7S
CAS 号

1356847-85-2
中文名称

盐酸仑氨苄西林 d5 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. FUMIO OGINO, et al. ACUTE TOXICITY OF LENAMPICILLIN HYDROCHLORIDE (KBT-1585) IN MICE, RATS AND DOGS

    [3]. Yamabe S, et al. Non-mutagenicity of KBT-1585, a novel ester of ampicillin.Chemioterapia. 1984 Feb;3(1):60-2.

    [4]. Fujita K, et al. Clinical evaluation of lenampicillin in the treatment of superficial suppurative skin and soft tissue infection. A double-blind study comparing amoxicillin.Jpn J Antibiot. 1985 Jul;38(7):1794-818.

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