24-Norursodeoxycholic acid-d5(Synonyms: Norucholic acid-d5; nor-UDCA-d5)

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24-Norursodeoxycholic acid-d5 (Synonyms: Norucholic acid-d5; nor-UDCA-d5)

24-Norursodeoxycholic acid-d5 (Norucholic acid-d5) 是 24-Norursodeoxycholic acid 的氘代物。24-norursodeoxycholic acid (Norucholic acid) 是侧链缩短的 UDCA 的 C23 同系物，具有有效的抗胆汁淤积，抗炎和抗纤维化特性。

24-Norursodeoxycholic acid-d5(Synonyms: Norucholic acid-d5; nor-UDCA-d5)

24-Norursodeoxycholic acid-d5 Chemical Structure

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生物活性

24-Norursodeoxycholic acid-d5 (Norucholic acid-d5) is the deuterium labeled 24-Norursodeoxycholic acid. 24-norursodeoxycholic acid (Norucholic acid) is a side chain-shortened C23 homologue of UDCA and has shown potent anti-cholestatic, anti-inflammatory and anti-fibrotic properties.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

383.58

Formula

C23H33D5O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Fickert P, et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology. 2006 Feb;130(2):465-81.

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