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Ruboxistaurin-d6 hydrochloride (Synonyms: 鲁伯斯塔盐酸盐 d6 (盐酸盐))
Ruboxistaurin-d6 (LY333531-d6) hydrochloride) 是 Ruboxistaurin hydrochloride 的氘代物。Ruboxistaurin (LY333531) hydrochloride 是一种具有口服活性,选择性 PKC beta 抑制剂(Ki=2 nM),Ruboxistaurin hydrochloride 表现出 ATP 依赖的竞争性抑制 PKC beta I,其 IC50 为4.7 nM。Ruboxistaurin hydrochloride 对 PKC beta II 的 IC50 为 5.9 nM。
Ruboxistaurin-d6 hydrochloride Chemical Structure
CAS No. : 1794767-04-6
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生物活性 |
Ruboxistaurin-d6 (LY333531-d6) hydrochloride is the deuterium labeled Ruboxistaurin hydrochloride. Ruboxistaurin (LY333531) hydrochloride is an orally active, selective PKC beta inhibitor (Ki=2 nM). Ruboxistaurin hydrochloride exhibits ATP dependent competitive inhibition of PKC beta I with an IC50 of 4.7 nM. Ruboxistaurin hydrochloride inhibits PKC beta II with an IC50 of 5.9 nM[1][2]. |
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体外研究 (In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
511.04 |
Formula |
C28H23D6ClN4O3 |
CAS 号 |
1794767-04-6 |
中文名称 |
鲁伯斯塔盐酸盐 d6 (盐酸盐) |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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