L-Aspartic acid 13C(Synonyms: L-天冬氨酸 13C)

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L-Aspartic acid 13C (Synonyms: L-天冬氨酸 13C) 纯度: ≥98.0%

L-Aspartic acid 13C 是13C 标记的L-Aspartic acid。L-Aspartic acid 是一种氨基酸，被证明是一种结肠特异性药物输送的前体药物。

L-Aspartic acid 13C(Synonyms: L-天冬氨酸 13C)

L-Aspartic acid 13C Chemical Structure

CAS No. : 81201-97-0

规格 价格 是否有货 数量
5 mg ￥3400 In-stock
10 mg ￥5300 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

L-Aspartic acid 13C is a 13C labeled L-Aspartic acid. L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly[1][2].

体外研究
(In Vitro)

L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

134.10

Formula

C313CH7NO4
CAS 号

81201-97-0
中文名称

L-天冬氨酸 13C
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 5 mg/mL (37.29 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 7.4571 mL 37.2856 mL 74.5712 mL
5 mM 1.4914 mL 7.4571 mL 14.9142 mL
10 mM 0.7457 mL 3.7286 mL 7.4571 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.

    [2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.

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