Aplyronine A

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Aplyronine A 

Aplyronine A 是一种特异性肌动蛋白解聚剂。 Aplyronine A 具有抗肿瘤和凋亡作用。 Aplyronine A 可用于癌症、肌肉收缩、细胞运动和细胞分裂的研究。

Aplyronine A

Aplyronine A Chemical Structure

CAS No. : 151923-84-1

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Aplyronine A 相关产品

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生物活性

Aplyronine A is a specific actin-depolymerizing agent. Aplyronine A has antitumor and apoptosis effect. Aplyronine A can be used for the research of cancer and muscle contraction, cell motility and cell division[1].

IC50 & Target

IC50: 0.01 nM (HeLa S3 cells)[1].
EC50: 1.3 μM (F-actin)[1]

体外研究
(In Vitro)

Aplyronine A (compound 1) has cytotoxicity against HeLa S3 cells with an IC50 value of 0.01 nM[1].
Aplyronine A depolymerizes fibrous actin (F-actin) and inhibits the polymerization of actin with an EC50 value of 1.3 μM in vitro actin-depolymerizing assay[1].
Aplyronine A (0-1 μM, 0-2 h) causes prominent caspase-dependent apoptosis in human epithelial carcinoma HeLa S3 cells[1].
Aplyronine A (100 nM, 24 h) causes malfunction of cell adhesion and dephosphorylation of focal adhesion kinase with apoptosis[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Aplyronine A 相关抗体:

Western Blot Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 0-1 μM
Incubation Time: 0-2 h
Result: Induced the dephosphorylation of FAK in HeLa S3 cells.

Apoptosis Analysis[1]

Cell Line: HeLa S3 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Significantly reduced cellular viabilities in tumor cells and significant activation of caspase 3 in HeLa S3 cells.

体内研究
(In Vivo)

Aplyronine A (0.08 mg/kg) exhibits remarkable antitumor activities in vivo against P388 murine leukemia cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1076.44

Formula

C59H101N3O14

CAS 号

151923-84-1

结构分类
  • Alkaloids
  • Others
初始来源
  • 动物

Aplysia kurodai

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Masaki Kita, et al. Fluorescent aplyronine a: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells. Chembiochem. 2012 Aug 13;13(12):1754-8, 1702.  [Content Brief]

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