Homobutein

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Homobutein 

Homobutein 是一种天然查尔酮 (可存在于许多药用植物、水果、蔬菜、香料和坚果中) 和有效的 HDACs/NF-κB 双重抑制剂，其 IC50 值分别为 190 和 38 μM。Homobutein 也是一种铁离子 (II 和 III) 螯合剂，具各种活性，包括抗癌，抗炎，抗寄生虫和抗氧化活性。

Homobutein

Homobutein Chemical Structure

CAS No. : 34000-39-0

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Homobutein 相关产品

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生物活性

Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation[1][2][3][4].

IC50 & Target

Toxoplasma

 

体外研究
(In Vitro)

Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells[1].
Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1].
Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2].
Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 µM, respectively[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Homobutein 相关抗体:

Cell Viability Assay[1]

Cell Line: K562 cells
Concentration: 20, 24, 28, 32, 40 μM
Incubation Time: 2 h
Result: Showed inhibition of viability in K562 cells.

Cell Viability Assay[2]

Cell Line: Toxoplasma gondii RH-2F strain
Concentration: 1 μg/mL
Incubation Time: 72 h
Result: Surpressed 19.48% of the Toxoplasma gondii.

分子量

286.28

Formula

C16H14O5
CAS 号

34000-39-0
结构分类
  • Flavonoids
  • Chalcones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 豆科
  • 海南崖豆藤
  • 植物
  • 菊科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805.  [Content Brief]

    [2]. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20;92(3):369-383.  [Content Brief]

    [3]. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov;65(22):3029-32.  [Content Brief]

    [4]. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.

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