c-di-AMP (Synonyms: 环二腺苷酸; Cyclic diadenylate; Cyclic-di-AMP)

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c-di-AMP  (Synonyms: 环二腺苷酸; Cyclic diadenylate; Cyclic-di-AMP)

c-di-AMP (Cyclic diadenylate) 是 STING 激动剂，其与 STING 结合，从而激活 TBK3-IRF3 信号传导途径，随后引发 I 型 IFN 和 TNF 产生。c-di-AMP (Cyclic diadenylate) 是一种细菌第二信使，主要在革兰氏阳性细菌中，可调节细胞生长，存活以及毒力。c-di-AMP (Cyclic diadenylate) 也调节宿主免疫反应。c-di-AMP (Cyclic diadenylate) 可作为一种有效的粘膜佐剂，刺激体液和细胞反应。

c-di-AMP (Synonyms: 环二腺苷酸; Cyclic diadenylate; Cyclic-di-AMP)

c-di-AMP Chemical Structure

CAS No. : 54447-84-6

规格 价格 是否有货
500 μg ￥1200 询问价格 & 货期
1 mg ￥1800 询问价格 & 货期
5 mg ￥4800 询问价格 & 货期

* Please select Quantity before adding items.

c-di-AMP 的其他形式现货产品:

c-di-AMP disodium c-di-AMP diammonium

c-di-AMP 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].

IC50 & Target

STING[3]
体外研究
(In Vitro)

c-di-AMP (Cyclic diadenylate) signaling is a central factor in many Gram-positive bacteria regulating cell wall synthesis, potassium ion channels, DNA repair, and biofilm formation. c-di-AMP is also essential for cell growth, survival, and virulence of several well-known human pathogenic bacteria including S. aureus, L. monocytogenes, S. pyogenes, and Mycobacterium spp[1].
c-di-AMP (Cyclic diadenylate) combines with model antigens, such as OVA or β-Gal, acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

c-di-AMP 相关抗体:
分子量

658.41

Formula

C20H24N10O12P2
CAS 号

54447-84-6
性状

固体

颜色

White to off-white

中文名称

环二腺苷酸
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O 中的溶解度 : 3.33 mg/mL (5.06 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5188 mL 7.5941 mL 15.1881 mL
5 mM 0.3038 mL 1.5188 mL 3.0376 mL
10 mM — — —

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

=

浓度

×

体积

×

分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×

体积 (start)

V1

=

浓度 (final)

C2

×

体积 (final)

V2

扫码获得
动物溶解方案

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果
工作液所需浓度 : mg/mL

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纯度 & 产品资料

纯度: 99.29%

Data Sheet (610 KB) SDS (251 KB)

COA (265 KB) HNMR (181 KB) RP-HPLC (222 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Fahmi T, et al. c-di-AMP: An Essential Molecule in the Signaling Pathways that Regulate the Viability and Virulenceof Gram-Positive Bacteria. Genes (Basel). 2017 Aug 7;8(8).  [Content Brief]

    [2]. Ning H, et al. Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous AdjuvantInduces Elevated Immune Responses After Mycobacterium tuberculosis Infection. Front Immunol. 2019 Jul 3;10:1519.  [Content Brief]

    [3]. Ebensen T, et al. The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and QualitativeEnhanced Immune Responses Post Immunization. Front Cell Infect Microbiol. 2019 Feb 19;9:31.  [Content Brief]

    [4]. Sanchez MV, et al. Intranasal delivery of influenza rNP adjuvanted with c-di-AMP induces strong humoral and cellularimmune responses and provides protection against virus challenge. PLoS One. 2014 Aug 20;9(8):e104824.  [Content Brief]

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