Kuwanon A is a flavone derivative isolated from the root barks of the mulberry tree (Morus alba L.); inhibits nitric oxide production with an IC₅₀ of 10.5 μM.

IC50: 10.5 μM (nitric oxide)^[1]

Kuwanon A shows significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes with TG inhibition values of 47.1%. Kuwanon A also shows significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells with an IC₅₀ of 10.5 μM^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

420.45

C₂₅H₂₄O₆

62949-77-3

固体

Light yellow to yellow

桑皮酮A；桑酮A；桑黄酮A

• Flavonoids
• Flavones

• Phenols
• Polyphenols

• 植物
• 桑科
• 桑树

• 植物
• 其他科

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Yang ZG, et al. Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. Molecules. 2011 Jul 19;16(7):6010-22.  [Content Brief]

RAW264.7 cells are treated with Kuwanon A (3, 10, 20, 30, 100 μM). Cell viability is measured using the MTT assay^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

• [1]. Yang ZG, et al. Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. Molecules. 2011 Jul 19;16(7):6010-22.  [Content Brief]