12,13-DiHOME

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
12,13-DiHOME  纯度: ≥99.0%

12,13-DiHOME 是棕色脂肪组织 (BAT) 的刺激剂，也是一种产热脂肪因子，可激活 BAT 以响应寒冷。(±)12,13-DiHOME 通过促进 FA 转运蛋白 FATP1 和 CD36 向细胞膜的易位，激活 BAT 燃料摄取并增强耐寒性。(±)12,13-DiHOME 可用于代谢紊乱的研究。

12,13-DiHOME

12,13-DiHOME Chemical Structure

CAS No. : 263399-35-5

规格 价格 是否有货 数量
500μg（318.01 μM * 5 mL in Methyl acetate） ￥13000 In-stock

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生物活性

12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders[1].

体内研究
(In Vivo)

12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice fed a high-fat diet[1]
Dosage: 1 μg/kg
Administration: Retro-orbitally injection; once daily for 2 weeks
Result: Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.
Increased BAT-specific lipid uptake and improved oral lipid tolerance.
Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
Animal Model: To explore the biosynthesis of (±)12, 13-dihome in mice in vivo[1]
Dosage:
Administration: 7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result: Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.

分子量

314.46

Formula

C18H34O4
CAS 号

263399-35-5
性状

液体

颜色

Colorless to light yellow

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Solution, -20°C, 2 years
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (526 KB) SDS (251 KB)

COA (160 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Lynes MD, et al. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May;23(5):631-637.  [Content Brief]

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