Olivetol-d9(Synonyms: 橄榄醇 d9)

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Olivetol-d9 (Synonyms: 橄榄醇 d9)

Olivetol-d9 是 Olivetol 的氘代物。 Olivetol 是一种天然多酚类化合物,存在于地衣中,或由一些昆虫产生。Olivetol 竞争性地抑制大麻素受体 CB1CB2,抑制 CYP2C19CYP2D6 的活性,IC50 值和 Ki 值分别为 15.3 μM, 7.21 μM 和 2.71 μM, 2.87 μM

Olivetol-d9(Synonyms: 橄榄醇 d9)

Olivetol-d9 Chemical Structure

CAS No. : 137125-92-9

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生物活性

Olivetol-d9 is the deuterium labeled Olivetol. Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2[3]. Olivetol also inhibits CYP2C19 and CYP2D6 activi

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

189.30

Formula

C11H7D9O2

CAS 号

137125-92-9

中文名称

橄榄醇 d9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

    [2]. Jiang R, et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet. 2013;28(4):332-8.;Yamaori S, et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab

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