1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9(Synonyms: 1,2-Distearoyl-sn-glycero-3-PC-d9; DSPC-d9)

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1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 (Synonyms: 1,2-Distearoyl-sn-glycero-3-PC-d9; DSPC-d9)

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 是 1,2-Distearoyl-sn-glycero-3-phosphorylcholine 的氘代物。1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) 是一种脂质,可用于合成脂质体,是脂质纳米颗粒 (LNP) 系统中的脂质成分。

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9(Synonyms: 1,2-Distearoyl-sn-glycero-3-PC-d9;  DSPC-d9)

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 Chemical Structure

CAS No. : 326495-36-7

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生物活性

1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9 is deuterium labeled 1,2-Distearoyl-sn-glycero-3-phosphorylcholine. 1,2-Distearoyl-sn-glycero-3-phosphorylcholine (1,2-Distearoyl-sn-glycero-3-PC; DSPC) is a cylindrical-shaped lipid. 1,2-Distearoyl-sn-glyc

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

799.20

Formula

C44H79D9NO8P

CAS 号

326495-36-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Andrew D Miller. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.

    [2]. Jayesh A Kulkarni, et al. On the role of helper lipids in lipid nanoparticle formulations of siRNA. Nanoscale. 2019 Nov 21;11(45):21733-21739.

    [3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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