Prostaglandin E1-d9(Synonyms: Alprostadil-d9; PGE1-d9)

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Prostaglandin E1-d9 (Synonyms: Alprostadil-d9; PGE1-d9)

Prostaglandin E1-d9 是 Prostaglandin E1 的氘代物。Prostaglandin E1 是一种前列腺素受体配体，对小鼠 EP3、EP4、EP2、IP 和 EP1 的 Ki 值分别为 1.1 nM、2.1 nM、10 nM、33 nM 和 36 nM。Prostaglandin E1 诱导血管舒张并抑制血小板聚集。Prostaglandin E1 可作为血管扩张剂用于外

Prostaglandin E1-d9(Synonyms: Alprostadil-d9; PGE1-d9)

Prostaglandin E1-d9 Chemical Structure

CAS No. : 2342573-59-3

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生物活性

Prostaglandin E1-d9 is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.54

Formula

C20H25D9O5
CAS 号

2342573-59-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kiriyama M, et, al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

    [2]. Cattaneo MG, et, al. Alprostadil suppresses angiogenesis in vitro and in vivo in the murine Matrigel plug assay. Br J Pharmacol. 2003 Jan;138(2):377-85.

    [3]. Hauck EW, et, al. Prostaglandin E1 long-term self-injection programme for treatment of erectile dysfunction–a follow-up of at least 5 years. Andrologia. 1999;31 Suppl 1:99-103.

    [4]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

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