Fosamprenavir-d4(Synonyms: Amprenavir phosphate-d4; GW 433908-d4)

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Fosamprenavir-d4 (Synonyms: Amprenavir phosphate-d4; GW 433908-d4)

Fosamprenavir-d4 是 Fosamprenavir 氘代物。Fosamprenavir (Amprenavir phosphate; GW 433908) 是抗逆转录病毒蛋白酶抑制剂 Amprenavir 的磷酸酯前药,具有改善的溶解性。具有抗 HIV 感染作用

Fosamprenavir-d4(Synonyms: Amprenavir phosphate-d4;  GW 433908-d4)

Fosamprenavir-d4 Chemical Structure

CAS No. : 1133702-41-6

规格 是否有货
1 mg 询价
5 mg 询价

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生物活性

Fosamprenavir-d4 is deuterium labeled Fosamprenavir. Fosamprenavir (Amprenavir phosphate;GW 433908) is a phosphate ester prodrug of the antiretroviral protease inhibitor Amprenavir, with improved solubility[1]. Anti-HIV infection[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

589.63

Formula

C25H32D4N3O9PS

CAS 号

1133702-41-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Falcoz C, et al. Pharmacokinetics of GW433908, a prodrug of amprenavir, in healthy male volunteers. J Clin Pharmacol. 2002 Aug;42(8):887-98.

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